Proposal summaries
B280 - Gene/environment and gene/gene interactions in childhood conduct disorder and ADHD in a large longitudinally studied child cohort gene/environment and gene/gene interactions in anxiety/dysphoria in ALSPAC children - 01/03/2002
This is a gene-environment and gene-gene interaction study in a longitudinal child cohort to investigate the role in childhood behavioural problems of abundant functional polymorphisms that have previously been linked to aggression and ADHD.
B60 - Epidemiology of childrens dysphonia - 01/03/2002
(No outline received).
B59 - Handedness and exposure to diagnostic ultrasound in utero - 01/03/2002
(No outline received).
B56 - Modelling risk and resilience in the relationship between language development behaviour and reading through to 8 years an exploration of the ALSPAC data set - 01/02/2002
(No outline received).
B55 - Studies of gene 216 in relation to asthma - 01/02/2002
(No outline received).
B54 - What are the genetic and environmental determinants of open angle glaucoma in a UK population - 01/02/2002
(No outline received).
B58 - Social variation in obesity and cardiovascular risk factors - 01/02/2002
(No outline received).
B57 - Taste test in ALSPAC - 01/02/2002
(No outline received).
B299 - ALSPAC data of particular relevance to economists - 01/01/2002
(No outline received).
B51 - Investigation of low bone mass to fractures in childhood - 01/01/2002
The broad aim of this project is to study the determinants of fracture risk in children using the ALSPAC cohort. ALSPAC is a large and unique dataset that recruited all pregnant women resident in Avon between April 1991 and December 1992. This has resulted in 14,000 children of whom 10,000 are under active follow-up. ALSPAC has comprehensive information from early pregnancy to now. From the time of the child's birth, many different aspects have been measured and collected on an annual basis. At aged 9, all children are undergoing a dual energy X-ray absorptiometry (DXA) to assess their bone mass.
This project has 4 specific aims: (1) to examine the association between bone mass measured at 9 years of age and fracture risk over the the following 2 years; (2) to examine the association between potential risk factors that are thought to affect fractures independently of bone mass (e.g. participation in sporting activities); (3) to examine the association between early life factors that are thought to effect bone accretion and subsequent peak bone mass, and lifetime fracture risk at aged 11 years (e.g. breastfeeding); and (4) to examine the association between possible endocrine determinants of early life growth (such as cord blood leptin) and lifetime fracture risk at aged 11.
B50 - Monogenic and polygenic influences on human fetal growth and development - 01/01/2002
(No outline received).
B296 - 1 The association of infant nutrition on childhood growth body composition 2 The association of infant nutrition on plasma lipid profile blood pressure in childhood - 01/01/2002
(No outline received).
B48 - Using human deciduous tooth enamel to measure prenatal exposure to trace elements and heavy metals - a new tool for epidemiology and fetal origins research - 01/01/2002
Whilst the main aim is to study asthma, we will also investigate relations with related respiratory and atopic outcomes, namely lung function, bronchial hyper-responsiveness, atopy, rhinitis and eczema.
B47 - Antecedents of attention deficit and hyperactive behaviour in childhood - 01/12/2001
The specific aims of this study are twofold: 1) to define and concurrently describe sub-groups of ADHD according to DSM-IV criteria based on parent and teacher report measures at 8 years of age. 2) to identify the factors from pregnancy through infancy, preschool and early school years that predict ADHD and test whether these are similar or different for three subtypes of ADHD and for boths sexes.
The proposed study will thus identify the affected children and provide an empirically tested model of the relevant environmental factors that increase the risk for or protect against ADHD. This information, highly relevant for developing effective preventative models. will furthermore provide the basis for future groundbreaking research at the molecular level, testing for gene-environment interactions (to be applied for separately). This will be possible due to recent developments in pinpointing promising candidate genes (Zametkin et al., 2001) and the fact that ALSPAC has DNA on 10,000 of the children and most of their mothers. Samples of paternal DNA are planned for the future.
B46 - The influence of diet physical activity levels and body composition on age at menarche in a contemporary cohort - 01/12/2001
To collect comprehensive information about diet in around 5000 10 year-old girls.
To collect anthropometric measurements by standard methods from around 5000 girls at age 10.
To obtain comprehensive information about physical activity patterns from around 5000 girls at age 10.
To obtain information on menarcheal status and pubertal stage from around 5000 girls up to age 12.5.
To relate dietary intakes and physical activty patterns to pubertal and menarcheal status.
B45 - Herbalism and homeopathic medication - 01/11/2001
(No outline received).
B88 - Disentangling the genetic environment and psychological determinants of eating disorders - 01/11/2001
(No outline received).
B43 - Orthodontic proposal - 01/11/2001
(No outline received).
B42 - Food allergy as a risk factor for severe asthma - 01/11/2001
(No outline received).
B41 - Year 3 Schools Project - 01/11/2001
(No outline received).