Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B280 - Gene/environment and gene/gene interactions in childhood conduct disorder and ADHD in a large longitudinally studied child cohort gene/environment and gene/gene interactions in anxiety/dysphoria in ALSPAC children - 01/03/2002

B number: 
B280
Principal applicant name: 
D Goldman (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Gene/environment and gene/gene interactions in childhood conduct disorder and ADHD in a large, longitudinally studied child cohort (gene/environment and gene/gene interactions in anxiety/dysphoria in ALSPAC children.
Proposal summary: 

This is a gene-environment and gene-gene interaction study in a longitudinal child cohort to investigate the role in childhood behavioural problems of abundant functional polymorphisms that have previously been linked to aggression and ADHD.

Date proposal received: 
Friday, 1 March, 2002
Date proposal approved: 
Friday, 1 March, 2002
Keywords: 
Mental Health, Genes, ADHD
Primary keyword: 

B60 - Epidemiology of childrens dysphonia - 01/03/2002

B number: 
B60
Principal applicant name: 
Prof Susan Roulstone (University of the West of England (UWE), Bristol)
Co-applicants: 
Title of project: 
Epidemiology of children's dysphonia.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 March, 2002
Date proposal approved: 
Friday, 1 March, 2002
Keywords: 
Speech & Language
Primary keyword: 

B59 - Handedness and exposure to diagnostic ultrasound in utero - 01/03/2002

B number: 
B59
Principal applicant name: 
Prof Francis Duck (University of Bath, UK)
Co-applicants: 
Title of project: 
Handedness and exposure to diagnostic ultrasound in utero.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 March, 2002
Date proposal approved: 
Friday, 1 March, 2002
Keywords: 
Autism, Motor Co-ordination, Neurology, Vision, Handedness
Primary keyword: 

B56 - Modelling risk and resilience in the relationship between language development behaviour and reading through to 8 years an exploration of the ALSPAC data set - 01/02/2002

B number: 
B56
Principal applicant name: 
Dr Jennifer Law (Durham University, UK)
Co-applicants: 
Title of project: 
Modelling risk and resilience in the relationship between language development, behaviour and reading through to 8 years: an exploration of the ALSPAC data set.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 February, 2002
Date proposal approved: 
Friday, 1 February, 2002
Keywords: 
Speech & Language
Primary keyword: 

B55 - Studies of gene 216 in relation to asthma - 01/02/2002

B number: 
B55
Principal applicant name: 
Prof John Holloway (University of Southampton, UK)
Co-applicants: 
Title of project: 
Studies of gene 216 in relation to asthma.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 February, 2002
Date proposal approved: 
Friday, 1 February, 2002
Keywords: 
Allergies, Genetics, Respiratory, Atopy, Asthma, Genes
Primary keyword: 

B54 - What are the genetic and environmental determinants of open angle glaucoma in a UK population - 01/02/2002

B number: 
B54
Principal applicant name: 
Miss Cathy E M Williams (University of Bristol, UK)
Co-applicants: 
Title of project: 
What are the genetic and environmental determinants of open angle glaucoma in a UK population?
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 February, 2002
Date proposal approved: 
Friday, 1 February, 2002
Keywords: 
Autism, Genetics, Motor Co-ordination, Neurology, Vision, Environmental Exposure
Primary keyword: 

B58 - Social variation in obesity and cardiovascular risk factors - 01/02/2002

B number: 
B58
Principal applicant name: 
Dr Imogen Rogers (University of Brighton, Brighton)
Co-applicants: 
Title of project: 
Social variation in obesity and cardiovascular risk factors.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 February, 2002
Date proposal approved: 
Friday, 1 February, 2002
Keywords: 
Endocrine, Growth, Obesity, Weight, Cardiovascular , Social Science, Stress, Social Conditions
Primary keyword: 

B57 - Taste test in ALSPAC - 01/02/2002

B number: 
B57
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Title of project: 
Taste test in ALSPAC.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 February, 2002
Date proposal approved: 
Friday, 1 February, 2002
Keywords: 
Autism, Motor Co-ordination, Neurology, Vision
Primary keyword: 

B299 - ALSPAC data of particular relevance to economists - 01/01/2002

B number: 
B299
Principal applicant name: 
Prof Carol Propper (Imperial College London, UK)
Co-applicants: 
Title of project: 
ALSPAC data of particular relevance to economists.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 January, 2002
Date proposal approved: 
Tuesday, 1 January, 2002
Keywords: 
Economics, Social Conditions
Primary keyword: 

B51 - Investigation of low bone mass to fractures in childhood - 01/01/2002

B number: 
B51
Principal applicant name: 
Dr Emma Margaret Clark (Royal National Hospital for Rheumatic Disease, UK)
Co-applicants: 
Prof Andy Ness (University of Bristol, UK)
Title of project: 
Investigation of low bone mass to fractures in childhood.
Proposal summary: 

The broad aim of this project is to study the determinants of fracture risk in children using the ALSPAC cohort. ALSPAC is a large and unique dataset that recruited all pregnant women resident in Avon between April 1991 and December 1992. This has resulted in 14,000 children of whom 10,000 are under active follow-up. ALSPAC has comprehensive information from early pregnancy to now. From the time of the child's birth, many different aspects have been measured and collected on an annual basis. At aged 9, all children are undergoing a dual energy X-ray absorptiometry (DXA) to assess their bone mass.

This project has 4 specific aims: (1) to examine the association between bone mass measured at 9 years of age and fracture risk over the the following 2 years; (2) to examine the association between potential risk factors that are thought to affect fractures independently of bone mass (e.g. participation in sporting activities); (3) to examine the association between early life factors that are thought to effect bone accretion and subsequent peak bone mass, and lifetime fracture risk at aged 11 years (e.g. breastfeeding); and (4) to examine the association between possible endocrine determinants of early life growth (such as cord blood leptin) and lifetime fracture risk at aged 11.

Date proposal received: 
Tuesday, 1 January, 2002
Date proposal approved: 
Tuesday, 1 January, 2002
Keywords: 
Bones
Primary keyword: 

B50 - Monogenic and polygenic influences on human fetal growth and development - 01/01/2002

B number: 
B50
Principal applicant name: 
Prof Andrew Hattersley (University of Exeter, UK)
Co-applicants: 
Title of project: 
Monogenic and polygenic influences on human fetal growth and development.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 January, 2002
Date proposal approved: 
Tuesday, 1 January, 2002
Keywords: 
Genetics, Growth, Obstetrics, Pregnancy, Fetal Growth
Primary keyword: 

B296 - 1 The association of infant nutrition on childhood growth body composition 2 The association of infant nutrition on plasma lipid profile blood pressure in childhood - 01/01/2002

B number: 
B296
Principal applicant name: 
Prof Richard Martin (University of Bristol, UK)
Co-applicants: 
Title of project: 
(1) The association of infant nutrition on childhood growth & body composition (2) The association of infant nutrition on plasma lipid profile & blood pressure in childhood.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 January, 2002
Date proposal approved: 
Tuesday, 1 January, 2002
Keywords: 
Blood Pressure, Growth, Nutrition
Primary keyword: 

B48 - Using human deciduous tooth enamel to measure prenatal exposure to trace elements and heavy metals - a new tool for epidemiology and fetal origins research - 01/01/2002

B number: 
B48
Principal applicant name: 
Prof Seif Shaheen (King's College London, UK)
Co-applicants: 
Prof John Henderson (University of Bristol, UK), Prof Andy Ness (University of Bristol, UK)
Title of project: 
Using human deciduous tooth enamel to measure prenatal exposure to trace elements and heavy metals - a new tool for epidemiology and fetal origins research?
Proposal summary: 

Whilst the main aim is to study asthma, we will also investigate relations with related respiratory and atopic outcomes, namely lung function, bronchial hyper-responsiveness, atopy, rhinitis and eczema.

Date proposal received: 
Tuesday, 1 January, 2002
Date proposal approved: 
Tuesday, 1 January, 2002
Keywords: 
Allergies, Biological Samples, Respiratory, Atopy, Teeth
Primary keyword: 

B47 - Antecedents of attention deficit and hyperactive behaviour in childhood - 01/12/2001

B number: 
B47
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Prof Dieter Wolke (University of Bristol, UK)
Title of project: 
Antecedents of attention deficit and hyperactive behaviour in childhood.
Proposal summary: 

The specific aims of this study are twofold: 1) to define and concurrently describe sub-groups of ADHD according to DSM-IV criteria based on parent and teacher report measures at 8 years of age. 2) to identify the factors from pregnancy through infancy, preschool and early school years that predict ADHD and test whether these are similar or different for three subtypes of ADHD and for boths sexes.

The proposed study will thus identify the affected children and provide an empirically tested model of the relevant environmental factors that increase the risk for or protect against ADHD. This information, highly relevant for developing effective preventative models. will furthermore provide the basis for future groundbreaking research at the molecular level, testing for gene-environment interactions (to be applied for separately). This will be possible due to recent developments in pinpointing promising candidate genes (Zametkin et al., 2001) and the fact that ALSPAC has DNA on 10,000 of the children and most of their mothers. Samples of paternal DNA are planned for the future.

Date proposal received: 
Saturday, 1 December, 2001
Date proposal approved: 
Saturday, 1 December, 2001
Keywords: 
ADHD, Antisocial Behaviour
Primary keyword: 

B46 - The influence of diet physical activity levels and body composition on age at menarche in a contemporary cohort - 01/12/2001

B number: 
B46
Principal applicant name: 
Dr Imogen Roberts (University of Bristol, UK)
Co-applicants: 
Title of project: 
The influence of diet, physical activity levels and body composition on age at menarche in a contemporary cohort.
Proposal summary: 

To collect comprehensive information about diet in around 5000 10 year-old girls.

To collect anthropometric measurements by standard methods from around 5000 girls at age 10.

To obtain comprehensive information about physical activity patterns from around 5000 girls at age 10.

To obtain information on menarcheal status and pubertal stage from around 5000 girls up to age 12.5.

To relate dietary intakes and physical activty patterns to pubertal and menarcheal status.

Date proposal received: 
Saturday, 1 December, 2001
Date proposal approved: 
Saturday, 1 December, 2001
Keywords: 
Diet, Physical Activity, Puberty
Primary keyword: 

B45 - Herbalism and homeopathic medication - 01/11/2001

B number: 
B45
Principal applicant name: 
Prof Edzard Ernst (University of Exeter, UK)
Co-applicants: 
Title of project: 
Herbalism and homeopathic medication
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Drugs
Primary keyword: 

B88 - Disentangling the genetic environment and psychological determinants of eating disorders - 01/11/2001

B number: 
B88
Principal applicant name: 
Prof Janet Treasure (King's College London, UK)
Co-applicants: 
Title of project: 
Disentangling the genetic environment and psychological determinants of eating disorders.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Diet, Eating Disorder, Genetics
Primary keyword: 

B43 - Orthodontic proposal - 01/11/2001

B number: 
B43
Principal applicant name: 
A Williams (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Orthodontic proposal.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Allergies, Environmental Exposure, Respiratory, Atopy, Teeth
Primary keyword: 

B42 - Food allergy as a risk factor for severe asthma - 01/11/2001

B number: 
B42
Principal applicant name: 
Prof Gideon Lack (King's College London, UK)
Co-applicants: 
Title of project: 
Food allergy as a risk factor for severe asthma.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Allergies, Asthma, Respiratory, Atopy, Diet
Primary keyword: 

B41 - Year 3 Schools Project - 01/11/2001

B number: 
B41
Principal applicant name: 
Prof Jean Golding (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Year 3 Schools Project.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Education
Primary keyword: 

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