Proposal summaries
B121 - Chronic fatigue disorders of sleep phase duration - 01/07/2003
(No outline received).
B128 - Maternal ingestion of phytoestrogens and their effect on maternal health and outcome of pregnancy - 01/07/2003
(No outline received).
B120 - Investigating the aetiology of chlamydia - associated with tubal factor infertility - 01/06/2003
(No outline received).
B119 - Neighbourhood and household influences on injuries to preschool children - 01/06/2003
Injuries caused by accidents are a particular problem in young children and children's injury rates vary considerably from place to place. Low-income neighbourhoods have higher child injury rates than high-income neighbourhoods, and recent research suggests that only part of the difference is due to variations in the social, economic and demographic composition of local populations. This research aims to find out the relative contributions of family characteristics and neighbourhood features to the risk of injury to children aged 0-4 years in Bristol and its surrounding region, to discover some of the mechanisms that create patterns of inequality. The objectives are:
1) to determine the risk factors acting at the level of the child, the household and the neighbourhood, and whether these risks act independently.
2) to determine whether residents' perceptions of neighbourhood and local social networks are related to geographical variations in the risk of injury.
3) to determine the size of effects and interactions between risk factors, and identify modifiable risk factors that might be subject to intervention.
4) to identify the scale (size of neighbourhoods) at which any effects of place are most evident.
B100 - To investigate dietary patterns of children consuming high salt levels throughout early childhood - 01/06/2003
(No outline received).
B118 - Expression of Interest Evidence and guidance Collaborating Centres - 01/06/2003
(No outline received).
B117 - Methods to deal with missing data in ALSPAC - 01/06/2003
Analyses of data from longitudinal studies are often complicated by the presence of missing values, caused
by participant dropout or non-response. Failure to allow for this can lead to both biased and inefficient
statistical analyses. Analyses ignoring problems caused by missing data are common. Statistical research has
generated better ways to deal with these problems, but the methods are technically challenging. The
proposed research will focus on the application of multiple imputation (MI) - the most flexible available
method - in longitudinal studies. We will demonstrate the potential of MI to reduce bias and increase
precision in analyses of data from the ALSPAC birth cohort study and the ART-CC and ART-LINC HIV
cohort collaborations. We will also clarify the circumstances in which analyses allowing for missing data are
likely to have advantages over simpler methods. We will develop a framework for simulations that allow
evaluation of characteristics of imputation procedures, and use both simulations and analyses of longitudinal
data to examine how to deal with the model complexity that characterises application of these procedures.
We will adapt existing software to improve model diagnostics that may alert the user to problems in
imputation procedures and to facilitate sensitivity analyses that examine robustness of results to data that are
missing not at random MNAR). We will work with members of the CONSORT and STROBE groups, and
with journal editors, to provide guidelines on reporting analyses that deal with missing data.
B116 - Risk factors for the onset of depression in adolescence neuro-endocrine mechanisms and sex differences - 01/06/2003
(No outline received).
B110 - Bladder and bowel continence - 01/05/2003
Generalised Growth Mixture Models will enable us to divide the children into different groups (cluster-analysis style) and fit a different trajectory for each group. In the graph below, the y-axis is the probability of being dry at night. Preliminary analysis using data up to 91 months suggests 4 different groups: normal children, delayed dryness, severely delayed dryness and a relapse group.
Group membership can then be used as either a multinomial outcome or as a predictor for further analysis into the causes/effects of subnormal development of continence. The intention is to produce one methodological paper on the subject of fitting such models and then further epidemiological papers using the resulting groups.
B115 - Social and cultural determinants of health - 01/05/2003
(No outline received).
B114 - Fluoride exposure and dental caries - 01/05/2003
(No outline received).
B113 - Diet obesity and DXA - 01/05/2003
(No outline received).
B112 - Preparation for data sharing in the large birth cohort studies - 01/05/2003
(No outline received).
B108 - Developmental predictors of early onset mood disorders - 01/04/2003
(No outline received).
B107 - An investigation of the relationship between allergic sensitisation immunogenetic susceptibility and the risk of childhood common acute lymphoblastic leukaemia - 01/04/2003
(No outline received).
B105 - Genetic and epidemiological study of varicella infection in childhood with particular reference to the CCR5/CCR2 gene region the CC chemokine gene region the MHC III gene region the 5q31-33 gene region and IFN gamma and IF - 01/04/2003
(No outline received).
B104 - Factors influencing detection and treatment of children with Attention Deficit Hyperactivity Disorder - 01/03/2003
B103 - A prospective cohort study of the determinants of skeletal development in childhood - 01/03/2003
(No outline received).
B101 - Healthy eating behavioural and functional genomics of the disorders of eating - 01/03/2003
(No outline received).
B292 - Samples for fatty acid analyses antenatal and F7 plus maternal trace metal samples for Hg analysis at CDC - 01/03/2003
(No outline received).