Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B29 - Risk factors for obesity in contemporary children - 01/09/2001

B number: 
B29
Principal applicant name: 
Prof John Reilly (University of Strathclyde, UK)
Co-applicants: 
Dr Andrea Sherriff (University of Glasgow, UK)
Title of project: 
Risk factors for obesity in contemporary children.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 September, 2001
Date proposal approved: 
Saturday, 1 September, 2001
Keywords: 
Endocrine, Growth, Obesity, Weight
Primary keyword: 

B26 - Early onset eating psychopathy - collision between satiety and constraint - 01/08/2001

B number: 
B26
Principal applicant name: 
Prof Alan Stein (University of Oxford, UK)
Co-applicants: 
Title of project: 
Early onset eating psychopathy - collision between satiety and constraint.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Diet, Eating disorders
Primary keyword: 

B25 - The SPINK gene and eczema - 01/08/2001

B number: 
B25
Principal applicant name: 
Prof Robin Callard (University College London, UK)
Co-applicants: 
Title of project: 
The SPINK gene and eczema.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Eczema, Genetics, Skin, Genes
Primary keyword: 

B24 - A gene-environment study of infection susceptibility in pre-term delivery - 01/08/2001

B number: 
B24
Principal applicant name: 
Dr Mark Turner (University of Liverpool, UK)
Co-applicants: 
Title of project: 
A gene-environment study of infection susceptibility in pre-term delivery.
Proposal summary: 
Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Genetics, Infection, Obstetrics, Pregnancy, Genes, Pre term
Primary keyword: 

B22 - Cadmium exposure and renal damage in adults and children living near zinc smelter in Avonmouth - 01/08/2001

B number: 
B22
Principal applicant name: 
Dr Lars Jarup (Imperial College London, UK)
Co-applicants: 
Title of project: 
Cadmium exposure and renal damage in adults and children living near zinc smelter in Avonmouth.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Environmental Exposure
Primary keyword: 

B20 - Long-term effects of early postnatal stress - 01/08/2001

B number: 
B20
Principal applicant name: 
Dr Tom O'Connor (University of Rochester Medical Centre, USA)
Co-applicants: 
Title of project: 
Long-term effects of early postnatal stress.
Proposal summary: 

Specific aims of this research are to a) examine the long-term effects of prenatal anxiety on dimensional and diagnostic measures of psychopathology in early adolescence; b) assess the role of the HPA axis underlying the links between prenatal anxiety on adolescent psychopathology and stress vulnerability; c) test competing hypotheses concerning the processes by which prenatal anxiety has direct, mediated or moderated effects on adolescent psychopathology; and d) test the hypothesis that the effects of prenatal anxiety/stress on behavioral/emotional problems in early adolescence are moderated by genetic risk.

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Autism, Biological Samples, Depression, Mental Health, Motor Co-ordination, Neurology, Stress, Vision
Primary keyword: 

B18 - Determinants consequences of total energy expenditure and energy expended on physical activity in a representative contemporary sample of 10/11 year olds - 01/08/2001

B number: 
B18
Principal applicant name: 
Prof John Reilly (University of Strathclyde, UK)
Co-applicants: 
Title of project: 
Determinants & consequences of total energy expenditure and energy expended on physical activity in a representative contemporary sample of 10/11 year olds.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Physical Activity, Physical Fitness
Primary keyword: 

B11 - The ALSPAC cell lines - 01/07/2001

B number: 
B11
Principal applicant name: 
Prof Marcus Pembrey (University of Bristol, UK)
Co-applicants: 
Title of project: 
The ALSPAC cell lines.
Proposal summary: 

The overall aim of this grant was to create a Lymphoblastoid Cell Line (LCL) collection from children and parents participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). The study has collected data on a scale and with a richness unprecedented in the field of epidemiological study and the generation of the cell line bank would provide material for further genetic, gene expression and metabolomic research.

Development of the resource initially involved establishing a cell culture facility with robotic cell maintenance systems, development of a bespoke Laboratory Information Management System (LIMS) and development of protocols for the transformation and growth of LCLs. Once these systems were in place LCL production would become a routine laboratory procedure enabling cell lines to be produced from all cohort members who consented to cell line production.

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Genetics
Primary keyword: 

B10 - Blood pressure central obesity and insulin sensitivity in early childhood - associated with adrenal function birthweight and early growth - 01/07/2001

B number: 
B10
Principal applicant name: 
Prof David Dunger (University of Cambridge, UK)
Co-applicants: 
Title of project: 
Blood pressure, central obesity and insulin sensitivity in early childhood - associated with adrenal function, birthweight and early growth
Proposal summary: 

At UCLH we run a nationally used service for investigation of adrenal disease based on urine steroid analysis. We frequently get referred samples from children with early pubertal development which we attribute to adrenarche. From epidemiological studies we have conducted in collaboration with Professor Baker in Southampton we have examined changes in adrenal function in 9 year old children in Salisbury. In 24 hour urine collections both adrenal androgen and cortisol metabolites were quantified. Urinary androgen excretion was higher in children who had been light at birth. A 1 kg decrease in birthweight was associated with a 40% increase in androgen excretion. In contrast the relationship with urinary cortisol excretion was U-shaped with higher outputs at the extremes of birthweight. Birthweight was associated with metabolite output independent of current weight, gender and gestational age at birth, indicating that the HPA function was related to fetal growth rather than prematurity. A reduced birth size has also been associated with cardiovascular disease risk and insulin-dependent diabetes. High blood pressure and cardiac hypertrophy may be the consequence of the hyperactive adrenal secreting both cortisol and adrenal androgens from early puberty.

In children with asthma at 8 years of age there is absence of adrenal androgen output. This leads to a reduction in growth rate such that asthmatic children at this stage are shorter than their peers. As they go into puberty they catch-up on the lost height. Loss of adrenal androgens is a feature of many sytemic illnesses (severe burns, HIV and AIDS) and may be linked with states of immune suppression. Children with diabetes would be another group worth investigating.

In keeping with the objectives of the ALSPAC study these children would be worth studying in the same way with the aim of clarifying:

* Adrenal function in relation to birth weight

* Adrenal function in relation to parental adrenal function

* Adrenal function in asthmatic children

In addition to examining the balance of adrenal androgens and cortisol the urine data can be examined to establish whether changes would be due to increased circulating levels or due to changes in the degradative process for cortisol through it's metabolism to inactive cortisone. Thus metabolites of cortisol and cortisone will be examined along with the excretion rates of the free hormones themselves.

24 hour urine samples would be desirable from the children and their parents in order to assess cortisol and adrenal androgen productions.

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Biological Samples, Cardiovascular , Endocrine, Obesity, Weight, Blood Pressure
Primary keyword: 

B279 - ALSPAC data of particular relevance to economists previously A24 - 01/07/2001

B number: 
B279
Principal applicant name: 
Prof Carol Propper (Imperial College London, UK)
Co-applicants: 
Title of project: 
ALSPAC data of particular relevance to economists (previously A24).
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Economics
Primary keyword: 

B17 - Alcohol use during pregnancy child development at 7 years and the influence of genotype on association - 01/07/2001

B number: 
B17
Principal applicant name: 
R Little (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Alcohol use during pregnancy, child development at 7 years, and the influence of genotype on association.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Autism, Genetics, Motor Co-ordination, Neurology, Vision, Alcohol, Pregnancy
Primary keyword: 

B16 - Antibiotic resistance - 01/07/2001

B number: 
B16
Principal applicant name: 
Dr Michael Millar (Barts and London School of Medicine, UK)
Co-applicants: 
Title of project: 
Antibiotic resistance.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Infection
Primary keyword: 

B15 - The genetic environmental aetiology of anxiety in mothers - 01/07/2001

B number: 
B15
Principal applicant name: 
Dr Jonathan Evans (University of Bristol, UK)
Co-applicants: 
Title of project: 
The genetic & environmental aetiology of anxiety in mothers.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Depression, Mental Health, Mothers, Genetics
Primary keyword: 

B14 - A comparison of parental questionnaires and a system of professional child health surveillance in identifying developmental impairments - 01/07/2001

B number: 
B14
Principal applicant name: 
Prof Alan Emond (University of Bristol, UK)
Co-applicants: 
Title of project: 
A comparison of parental questionnaires and a system of professional child health surveillance in identifying developmental impairments.
Proposal summary: 

This project will investigate how well parents and health professionals can identify developmental problems in preschool children, using the ALSPAC study, a total birth cohort of 14,138 children born in 1991-2.

We will test whether parents are the first to identify impairments in their children and whether questionnaires can be an effective method of selecting children for further professional assessment in the pre-school period.

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Autism, Motor Co-ordination, Neurology
Primary keyword: 

B12 - Vegetarian diet and health - 01/07/2001

B number: 
B12
Principal applicant name: 
Dr Kate Northstone (University of Bristol, UK)
Co-applicants: 
Title of project: 
Vegetarian diet and health.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 July, 2001
Date proposal approved: 
Sunday, 1 July, 2001
Keywords: 
Diet, Eating disorders
Primary keyword: 

B7 - Hearing - 01/06/2001

B number: 
B7
Principal applicant name: 
Dr Judith Gravel (RIP) (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Hearing.
Proposal summary: 

(No proposal form received).

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Friday, 1 June, 2001
Keywords: 
Genetics, Hearing
Primary keyword: 

B6 - Proximity to overhead power lines and depression - 01/06/2001

B number: 
B6
Principal applicant name: 
A Preece (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Proximity to overhead power lines and depression.
Proposal summary: 

(No proposal form received).

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Friday, 1 June, 2001
Keywords: 
Depression, Environmental Exposure, Mental Health
Primary keyword: 

B5 - Thiomersal in DTP immunisations and long term development of this child - 01/06/2001

B number: 
B5
Principal applicant name: 
E Milller (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Thiomersal in DTP immunisations and long term development of this child.
Proposal summary: 

N/A

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Friday, 1 June, 2001
Keywords: 
ADHD, Antisocial Behaviour, Development, Immunity, Infection, Neurology
Primary keyword: 

B3 - An investigation into environmental influences on skeletal mineralisation during childhood - 01/06/2001

B number: 
B3
Principal applicant name: 
Dr Jon Tobias (University of Bristol, UK)
Co-applicants: 
Dr Ann Prentice (MRC Human Nutrition Research, UK), Prof David Dunger (University of Cambridge, UK), Prof Steve Humphries (University College London, UK)
Title of project: 
An investigation into environmental influences on skeletal mineralisation during childhood.
Proposal summary: 

This project aimed to examine whether skeletal development in childhood is programmed by early life factors, by studying the relationship between maternal diet as assessed by food frequency questionnaire (FFQ), other determinants of maternal nutrition such as smoking and exercise, and bone mass acquisition in childhood. The latter was assessed by measuring total body bone mineral content (BMC), bone area and bone mineral density (BMD) by performing total body DXA scans in 7000 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort at age nine. Regional development at sites such as the spine, upper and lower limbs was also evaluated. In further studies, we aimed to explore the mechanisms involved in any such programming effect by examining the role of genetic factors by studying associations between DXA parameters and single nucleotide polymorphisms (SNPs) in different genes.

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Friday, 1 June, 2001
Keywords: 
Bones
Primary keyword: 

B106 - Mannose binding lectin genotype and preterm labour and delivery - 01/06/2001

B number: 
B106
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Title of project: 
Mannose binding lectin genotype and preterm labour and delivery.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Friday, 1 June, 2001
Keywords: 
Infection
Primary keyword: 

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