B787 - Investigating the role of novel glycaemic trait variants in fetal and childhood growth - 13/02/2009
B number:
B787
Principal applicant name:
Prof Mark McCarthy (Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), UK)
Co-applicants:
Dr In?s Barroso (Wellcome Trust Sanger Institute, London, UK), Prof George Davey Smith (University of Bristol, UK), Dr Dave Evans (University of Bristol, UK), Prof Tim Frayling (Peninsula Medical School, University of Plymouth, UK), Dr Rachel Freathy (Peninsula Medical School, University of Plymouth, UK), Prof Andrew Hattersley (Peninsula Medical School, University of Plymouth, UK), Dr Inga Prokopenko (Wellcome Trust Centre for Human Genetics, UK), Dr Nic Timpson (University of Bristol, UK)
Title of project:
Investigating the role of novel glycaemic trait variants in fetal and childhood growth.
Proposal summary:
We propose to test the following hypotheses:
1) Fetal genotype and maternal genotype are associated with fetal growth measures (birth weight, birth head circ, birth length).
2) Fetal genotype and maternal genotype ar associated with measures of growth in infancy and childhood (height, weight, BMI, fat mass etc).
3) Child's genotype is associated with intermediate traits related to Type II diabetes including fasting insulin, fasting glucose and insulin secretion and related metabolic traits (in the subset of offspring with OGTT data).
Date proposal received:
Friday, 13 February, 2009
Date proposal approved:
Friday, 13 February, 2009
Keywords:
Nutrition, Growth
Primary keyword: