Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B308 - Children in Poverty aspirations expectations and attitudes to education - 01/09/2006

B number: 
B308
Principal applicant name: 
Alissa Goodman (The Institute for Fiscal Studies, UK)
Co-applicants: 
Title of project: 
Children in Poverty: aspirations, expectations and attitudes to education.
Proposal summary: 

Children from deprived homes emerge from our schools with substantially lower levels of educational attainment. These educational deficits emerge early in children's lives, even before entry into school and widen throughout childhood.

But little is known about how family background affects education attainment. This project will consider the influences on children's skill development, in its broadest sense, focussing particularly on soft skills, and on attitudes to education amongst children from low-income backgrounds

Date proposal received: 
Friday, 1 September, 2006
Date proposal approved: 
Friday, 1 September, 2006
Keywords: 
Education
Primary keyword: 

B449 - Translating genome-wide association data from the WTCCC study into biological and clinical insights in type 2 diabetes - 01/09/2006

B number: 
B449
Principal applicant name: 
Prof Tim Frayling (University of Exeter & Plymouth, UK)
Co-applicants: 
Prof David McCarthy (London Metropole University, UK), Dr Michael Weedon (Peninsula Medical School, University of Plymouth, UK), Prof Andrew Hattersley (Not used 0, Not used 0)
Title of project: 
Translating genome-wide association data from the WTCCC study into biological and clinical insights in type 2 diabetes
Proposal summary: 

Aim.

To test the hypothesis that variation in genes in key beta-cell pathways increases the risk of type 2 diabetes.

Aim: To use large-scale genome wide association data from the Wellcome Trust Case Control Consortium (WTCCC) as a platform for a systematic assessment of the role of variation in beta-cell genes in the aetiology of type 2 diabetes.

Date proposal received: 
Friday, 1 September, 2006
Date proposal approved: 
Friday, 1 September, 2006
Keywords: 
Primary keyword: 

B389 - Use of Genetic-Variation to Explore Associations between Early Life Nutrition - 21/08/2006

B number: 
B389
Principal applicant name: 
Dr Sarah J Lewis (University of Bristol, UK)
Co-applicants: 
Prof George Davey Smith (University of Bristol, UK), Prof Debbie A Lawlor (University of Bristol, UK)
Title of project: 
Use of Genetic-Variation to Explore Associations between Early Life Nutrition.
Proposal summary: 

To determine whether exposure to specific dietary factors in utero and infancy influences cognition.

Specific Hypotheses:

1) Suboptimum levels of specific nutrients such as folate and omega-3 fatty acids in utero lead to impaired neurodevelopment and low cognitive ability.

2) Polymorphisms in genes which metabolise nutrients are associated with neurodevelopment in infancy and can be used to infer causal relationships between specific nutrients and cognition.

3) Maternal genotype and corresponding offspring genotype, jointly determine neurodevelopment in infancy and childhood. Associations with maternal genotype, independent of offspring genotype, will support the role of the prenatal environment.

Neuroanatomical and neurophysiological studies show that brain development occurs most rapidly during fetal development and in infancy. Nutrition is probably the single greatest environmental influence both on the fetus and neonate, and plays a necessary role in the maturation and functional development of the central nervous system. Therefore a lack of any nutrient required for brain development may be related to neurodevelopmental diseases such as autism as well as influencing general cognition. Nutrients found to be lacking in the mothers' diet could, if shown to be related to brain development, be modified to prevent disease and ensure that the childs' cognitive ability is not impaired.

We plan to:

1) Genotype mothers and their offspring with respect to candidate polymorphisms which influence nutrient intake, metabolism, transport or cellular uptake.

2) Determine associations between the above maternal and infant polymorphisms and childhood cognition.

3) Stratifying by offspring genotype, determine associations between maternal genotype and offspring cognition.

4) Investigate whether the above polymorphisms are associated with cigarette smoking, socioeconomic status, reproductive factors and other potential confounders in the mothers, to confirm that developmental outcome associations with genotypes are not confounded.

Genotype analysis

Variation in genes which alter the availability of specific nutrients will be exploited in this project. Suitable candidate genes include those which are; a) associated with nutrient intake, such as the lactase gene, polymorphisms of which determine lactose intolerance and therefore intake of lactose b) involved in nutrient metabolism, for example there are several enzymes involved in the biosynthesis of the omega-3 fatty acid DHA from its' precursors in the diet including cycloxygenase (COX), lipoxygenase (LOX) and delta-5 desaturase, c) important in the transport and internalization of nutrients into target cells, such as the choline transporter (CHT1) gene. Genotyping of SNPs will be carried by K-Biosciences (http://www.kbioscience.co.uk).

Outcome measurements

The primary outcome will be the Wechsler Intelligence Scale for Children (WISC)-III, which is a UK measure of cognitive ability (IQ) measured at the focus clinic at age 8 1/2 (score available for 7188 children). Education is strongly influenced by political and social factors and is therefore less likely to be due to mothers' diet, however, educational scores will be secondary outcomes in this study as education is likely to be important in the pathway between cognition and later health. Additional outcome measures will be included in this project as they may provide insights into specific aspects of neurodevelopment that may be particularly sensitive to maternal dietary influences in-utero. The secondary outcomes are:

* Wechsler Objective Reading Dimensions (WORD) test and the Wechsler Objective Language Dimension (WOLD) Test - which measure reading and language respectively,

* Social Communication Disorders Checklist (SCDC), - measures social interaction and communication skills.

* Development and Well-Being Assessment (DAWBA) and the Strengths and Difficulties Questionaire (SDQ) - both designed to measure conduct problems, emotional behaviour and hyperactivity,

* School and hospital diagnosed learning difficulties - will pick up individuals with clinically diagnosed conditions.

* SATS test scores and GCSE results are included in the list of outcomes to determine whether dietary effects on cognition, are translated into school performance. We would only explore associations with this outcome where there was a positive association of a maternal dietary factor with cognitive ability. Thus, this would extend the primary analysis to provide an indication of whether the effect of maternal diet on cognition had an important effect on performance.

* Head circumference- this is a more crude measure of brain development than the other outcome measures proposed in this grant. However, it was measured at birth for all children in the ALSPAC study and as this is an indicator which relates specifically to in-utero development.

The large number of tests generated by having several outcomes will increase the possibility of false positive results. In order to guard against this we will:

* Undertake secondary analyses only when there is an indication to do so from the primary analyses (e.g. with school performance)

* Seek to replicate any positive results (with primary or secondary outcomes) in other cohort studies as described in the proposal.

Date proposal received: 
Monday, 21 August, 2006
Date proposal approved: 
Monday, 21 August, 2006
Keywords: 
Autism, Diet, Genetics, Motor Co-ordination, Nutrition, Vision, Eating disorders, Dyslexia
Primary keyword: 

B388 - The Safety and Efficacy of Raspberry Leaf Herb in Pregnancy An Observational Study nested within the Avon Longitudinal Study of Parents and Children ALSPAC - 07/08/2006

B number: 
B388
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Title of project: 
The Safety and Efficacy of Raspberry Leaf Herb in Pregnancy: An Observational Study nested within the Avon Longitudinal Study of Parents and Children (ALSPAC)
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 7 August, 2006
Date proposal approved: 
Monday, 7 August, 2006
Keywords: 
Pregnancy, Nutrition
Primary keyword: 

B381 - An investigation into the relationship between Charles de Coti Marshs teaching and the use of complementary medicine products supplements and dietary habits of children and parents within the Avon Longitudinal Study of P - 10/07/2006

B number: 
B381
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Dr Pauline Emmett (University of Bristol, UK), Dr Kate Northstone (University of Bristol, UK), Mrs Jackie Bishop (University of Bristol, UK)
Title of project: 
An investigation into the relationship between Charles de Coti Marsh's teaching and the use of complementary medicine products, supplements and dietary habits of children (and parents?) within the Avon Longitudinal Study of Parents and Children (ALSPAC).
Proposal summary: 

The Arthritic Association is built upon the clear recommendations of Charles de Coti-Marsh for the use of diet, supplements and lifestyle for the amelioration of the symptoms of arthritis. The Home Treatment Programme includes recommendations of a diet of potassium-rich foods andincreased intake of fruit, nuts, vegetables and whole grains, low saturated fat intake, low sugar and salt intake, the use of supplements such as homeopathic Arnica, 'K' compound and Oil of Garlic and the advocation of a lifestyle that includes regular gentle exercise and adequate sleep.

However, as pointed out by the Association there is no evidence yet as to whether the use of such diets and/or treatments may prevent symptoms of arthritis and/or limb and other pain from actually occurring. We propose to use data collected in ALSPAC to assess whether there is any evidence to support such a hypothesis and also to investigate associations between the recommendations of the Home Treatment Programme upon ALSPAC parents with arthritis and parents and children with joint pain. In so doing, this investigation has the unique opportunity to examine these key factors by laying down foundations as to the pre-cursors of children developing arthritis in later life.

Date proposal received: 
Monday, 10 July, 2006
Date proposal approved: 
Monday, 10 July, 2006
Keywords: 
Diet
Primary keyword: 

B385 - Associations in the Diet and Physical Activity Patterns of 11 year old Children Avon Longitudinal Study of Parents and Children - 07/07/2006

B number: 
B385
Principal applicant name: 
Prof Russ Jago (University of Bristol, UK)
Co-applicants: 
Title of project: 
Associations in the Diet and Physical Activity Patterns of 11 year old Children: Avon Longitudinal Study of Parents and Children.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 7 July, 2006
Date proposal approved: 
Friday, 7 July, 2006
Keywords: 
Diet, Physical Activity, Exercise & Fitness, Eating disorders
Primary keyword: 

B382 - Deanfield Programme Renewal - 04/07/2006

B number: 
B382
Principal applicant name: 
Prof John Deanfield (University College London, UK)
Co-applicants: 
Title of project: 
Deanfield Programme Renewal.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 4 July, 2006
Date proposal approved: 
Tuesday, 4 July, 2006
Keywords: 
Biological Samples
Primary keyword: 

B379 - Does Impaired Autobiographical Memory Mediate Associations between Traumatic Life Events in Childhood and Subsequent Depression and Self-harm - 30/06/2006

B number: 
B379
Principal applicant name: 
Dr Jonathan Evans (University of Bristol, UK)
Co-applicants: 
Prof David Gunnell (University of Bristol, UK), Prof Glyn Lewis (University of Bristol, UK), Prof Mark Williams (University of Bristol, UK)
Title of project: 
Does Impaired Autobiographical Memory Mediate Associations between Traumatic Life Events in Childhood and Subsequent Depression and Self-harm?
Proposal summary: 

The aim of this study is to investigate the association between childhood depression, adversity and abuse, deficits in autobiographical memory measured at 13 years, and the subsequent emergence of new onsets of major depression and self-harm by 15 years.

Date proposal received: 
Friday, 30 June, 2006
Date proposal approved: 
Friday, 30 June, 2006
Keywords: 
Depression, Self-harm, Memory
Primary keyword: 

B378 - Long Term Effects of Bedsharing by Mothers and Infants - 26/06/2006

B number: 
B378
Principal applicant name: 
Prof Peter Fleming (University of Bristol, UK)
Co-applicants: 
Dr Peter Blair (University of Bristol, UK), Dr Shahrad Taheri (University of Birmingham, UK)
Title of project: 
Long Term Effects of Bedsharing by Mothers and Infants.
Proposal summary: 

Mother-baby bedsharing is associated with an increased risk of unexpected infant death, particularly for mothers who smoke or drink alcohol, but little is known of the potential beneficial effects of bedsharing (e.g. establishment or maintenance of breastfeeding), and recent US data has confirmed the beneficial effects of breastfeeding in reducing infant mortality. The Avon Longitudinal Study of Parents And Children (ALSPAC) has collected information on health, growth, development, medical, environmental and social factors from pregnancy to the present, in a cohort of 14,000 children born in 1991-2 and their families. Detailed information has been collected on sleep patterns, duration and place for the infants and their parents. Preliminary analysis of the data on sleep in infancy and childhood has shown that in the first 6 months 33-70% infants share a bedroom with their mother, and routine mother-baby bedsharing for night time sleep is common throughout infancy and early childhood, varying between 9% and 18%. Many factors (e.g. birthweight, breastfeeding), are associated with sleep patterns and duration, and, whilst short sleep duration in early infancy is associated with obesity in later childhood, breastfeeding (which is associated with bedsharing) may reduce the risk of obesity.

We will use complex statistical modelling techniques to analyse the data from ALSPAC children and families, to identify factors contributing to parents choices about bedsharing in infancy, together with any immediate or long term adverse consequences or benefits of bedsharing, room sharing or separate sleeping, for both children and mothers. The large size and completeness of the data from the ALSPAC cohort will allow us to take account of multiple psychological, medical, social and environmental factors that may have influenced decisions about infant care practices, and may themselves have been associated with potential benefits or adverse consequences (e.g. breastfeeding, maternal smoking, socio-economic deprivation, pacifier use).

Date proposal received: 
Monday, 26 June, 2006
Date proposal approved: 
Monday, 26 June, 2006
Keywords: 
Sleep Patterns
Primary keyword: 

B376 - Preventable Hearing Loss What is the Prevalence Penetrance and Phenotype of the Mitochondrial A1555G Mutation associated with Aminoglycoside-induced Hearing Loss - 25/06/2006

B number: 
B376
Principal applicant name: 
Prof Maria Bitner-Glindzicz (University College London, UK)
Co-applicants: 
S Rahman (Not used 0, Not used 0), Prof Marcus Pembrey (University of Bristol, UK)
Title of project: 
Preventable Hearing Loss: What is the Prevalence, Penetrance and Phenotype of the Mitochondrial A1555G Mutation, associated with Aminoglycoside-induced Hearing Loss?
Proposal summary: 

As suspected the prevalence of the m.1555Agreater than G mutation in the ALSPAC cohort was 1 in 540. This prevalence has potentially important implications for the use of aminoglycoside antibiotics in the UK. For this reason we wish to use the mothers of the ALSPAC children to validate the accuracy of the genotyping results.

Genotyping of both mothers and children provides internal quality control because this is a mitochondrial variant which is homoplasmic. So, any children who are positive for the mutation will have mothers who are postitive, and any children who are negative should not have a mother who is also negative.

Date proposal received: 
Sunday, 25 June, 2006
Date proposal approved: 
Sunday, 25 June, 2006
Keywords: 
Genetics, Hearing
Primary keyword: 

B399 - Birth Weight and Interleukin-1 Receptor Antagonist - 21/06/2006

B number: 
B399
Principal applicant name: 
Dr John Newell-Price (University of Sheffield, UK)
Co-applicants: 
Dr Sheila Francis (University of Sheffield, UK), Dr Lee Abbott (University of Sheffield, UK), Ms Hannah Blagnys (University of Sheffield, UK)
Title of project: 
Birth Weight and Interleukin-1 Receptor Antagonist.
Proposal summary: 

Aims

  • To use SNPs in linkage disequilibrium with IL-1RN*2 to genotype the 'Children in Focus' (CIF) cohort of the ALSPAC study.
  • To test for association of the inferred IL-1RN*2 genotype with birth weight.
Date proposal received: 
Wednesday, 21 June, 2006
Date proposal approved: 
Wednesday, 21 June, 2006
Keywords: 
Endocrine, Growth, Obesity, Birth weight, Genetics
Primary keyword: 

B375 - Sleep Stress and Mental Health - 16/06/2006

B number: 
B375
Principal applicant name: 
Prof Peter Fleming (University of Bristol, UK)
Co-applicants: 
Prof Stafford Lightman (University of Bristol, UK), Prof David Nutt (University of Bristol, UK), Dr Shahrad Taheri (University of Birmingham, UK)
Title of project: 
Sleep, Stress and Mental Health
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 16 June, 2006
Date proposal approved: 
Friday, 16 June, 2006
Keywords: 
Depression, Mental Health, Self-harm, Social Science, Stress, Sleep
Primary keyword: 

B393 - Dyslexia Genotypes - 16/06/2006

B number: 
B393
Principal applicant name: 
Prof Alan Emond (University of Bristol, UK)
Co-applicants: 
Julie Williams (University of Cardiff, UK)
Title of project: 
Dyslexia Genotypes.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 16 June, 2006
Date proposal approved: 
Friday, 16 June, 2006
Keywords: 
Genetics, Dyslexia
Primary keyword: 

B370 - Analysis of Homocysteine and B Vitamins in Relation to Several Outcomes in Mothers and Children - 15/06/2006

B number: 
B370
Principal applicant name: 
Prof Helga Refsum (University of Oxford, UK)
Co-applicants: 
Andrew David Smith (University of Oxford, UK)
Title of project: 
Analysis of Homocysteine and B Vitamins in Relation to Several Outcomes in Mothers and Children.
Proposal summary: 

Observational studies have shown an association between moderately elevated levels of plasma total homocysteine (tHcy) and a number of common diseases, including cardiovascular disease, pregnancy complications, foetal abnormalities, cognitive impairment and dementia, depression, osteoporosis, and mortality (see Refsum(1, 2) for relevant literature).

There have been very few studies that specifically addressed the questions:

1. 'Are raised tHcy levels, or low-normal levels of B vitamins in the mother associated with an increased risk of diseases or syndromes in their children?

2. 'Are raised tHcy levels, or low-normal levels of B vitamins in early life associated with an increased risk of diseases or syndromes?

Aims

The ALSPAC cohorts of mothers and children offer a unique opportunity to address the above broad questions. The aim is to see if there is any relation of these markers to health and well-being in mother and child, making use of the many outcome measures in ALSPAC. Some specific questions include:

  1. Are maternal tHcy and B vitamins related to pregnancy outcomes, such as size of baby at birth? (see our studies in Norway(3) & India(4))
  2. Is maternal tHcy related to placental vasculopathology?
  3. Are maternal tHcy and B vitamins related to markers of behaviour, cognition and school performance in children?
  4. Are tHcy and B vitamins in children related to markers of behaviour, cognition, and school performance?
  5. Are tHcy and B vitamins in children related to other disease or functional outcomes?
  6. Is there evidence of interactions between common polymorphisms in genes such as MTHFR, levels of folate, B12, tHcy and any of the outcome measures?

Date proposal received: 
Thursday, 15 June, 2006
Date proposal approved: 
Thursday, 15 June, 2006
Keywords: 
Autism, Biological Samples, Endocrine, Growth, Motor Co-ordination, Obesity, Vision, Weight, Dyslexia, Genetics
Primary keyword: 

B513 - Obesity prevention via physical activity promotion in school associations between habitual physical activity and executive function in the ALSPAC cohort - 11/06/2006

B number: 
B513
Principal applicant name: 
Prof John Reilly (University of Glasgow, UK)
Co-applicants: 
Prof Chris Riddoch (University of Bath, UK), Prof James Boyle (University of Strathclyde, UK), Abi Fisher (Not used 0, Not used 0), Dr Carol Joinson (University of Bristol, UK), Dr Sam Leary (University of Bristol, UK)
Title of project: 
Obesity prevention via physical activity promotion in school: associations between habitual physical activity and executive function in the ALSPAC cohort
Proposal summary: 

Aim :To test for associations between habitual physical activity and executive function at age 11- the ALSPAC cohort provides a unique opportunity to test this hypothesis due to its combination of large sample size, good measures of habitual physical activity (accelerometry) and executive function, and key confounders.

Date proposal received: 
Sunday, 11 June, 2006
Date proposal approved: 
Sunday, 11 June, 2006
Keywords: 
Endocrine, Physical Activity, Physical Fitness, Weight, Exercise & Fitness, Bone, Obesiy
Primary keyword: 

B368 - Preventing Type 2 Diabetes Through Interventions During Childhood - 09/06/2006

B number: 
B368
Principal applicant name: 
Dr Julian Hamilton-Shield (University of Bristol, UK)
Co-applicants: 
Title of project: 
Preventing Type 2 Diabetes Through Interventions During Childhood.
Proposal summary: 

(No outline received).

Date proposal received: 
Friday, 9 June, 2006
Date proposal approved: 
Friday, 9 June, 2006
Keywords: 
Diabetes, Endocrine, Growth, Obesity, Weight
Primary keyword: 

B365 - Obstretic Events and Subsequent Gynaecological Consequences - Feasibility Study - 05/06/2006

B number: 
B365
Principal applicant name: 
Miss Karen Birmingham (University of Bristol, UK)
Co-applicants: 
Prof Jean Golding (University of Bristol, UK), Dr Jon Heron (University of Bristol, UK), M Quinn (Not used 0, Not used 0)
Title of project: 
Obstretic Events and Subsequent Gynaecological Consequences - Feasibility Study.
Proposal summary: 

Denervation of pelvic organs taking place at vaginal delivery results in subsequent reinnervation and wide-ranging gynaecological symptoms e.g. vulvodynia, dyspareunia, chronic pelvic pain, irritative bladder symptoms, rectal hypersensitivity, menorrhagia and dysmenorrhoea (1-12). All benign myometrial pathology e.g. endometriosis, adenomyosis, leiomyomata, etc. has specific neural abnormalities in the spectrum of denervation-reinnervation (4-7). Reinnervation, in several different patterns, has been described in every female pelvic organ often in association with a prior history of difficult vaginal delivery including premature, or prolonged, maternal voluntary efforts (8-12).

In nulliparous women, straining to achieve defaecation has been demonstrated to cause specific neurological lesions in different pelvic viscera (8, 9, 12), and this mechanism, operating at the endometrial-myometrial nerve plexus , has been proposed as a source of impaired placentation in nulliparous pre-eclampsia. intrauterine growth retardation, abruption, placenta accrete/percreta (13, 14).

The question arises: "Do nulliparous women with severe obstetric problems e.g. early-onset preeclampsia. IUGR, preterm delivery, abruption, etc. suffer subsequent gynaecological symptoms e.g. menorrhagia, dysmenorrhoea, chronic pelvic pain, that require specific medical and surgical interventions e.g. hysteroscopy, laparoscopy, hysterectomy, etc. within the subsequent 10 years".

Date proposal received: 
Monday, 5 June, 2006
Date proposal approved: 
Monday, 5 June, 2006
Keywords: 
Obstetrics, Pregnancy
Primary keyword: 

B364 - Disordered eating in adolescence a longitudinal study of risk factors - 05/06/2006

B number: 
B364
Principal applicant name: 
Nadia Micali (King's College London, UK)
Co-applicants: 
Prof Janet Treasure (King's College London, UK), Dr Pauline Emmett (University of Bristol, UK), Dr Emily Simonoff (King's College London, UK)
Title of project: 
Disordered eating in adolescence: a longitudinal study of risk factors.
Proposal summary: 

The purpose of this study is to identify the risk factors related to the development of disordered eating and to determine risk factors for the persistence of disordered eating during adolescence. This will aid the development of early intervention and preventative strategies for disturbed eating in children and adolescents.

Date proposal received: 
Monday, 5 June, 2006
Date proposal approved: 
Monday, 5 June, 2006
Keywords: 
Eating Disorder
Primary keyword: 

B360 - Cigarette Smoking and Psychopathology Genetic and environmental effects on initiation and cessation among children and mothers in the ALSPAC cohort - 18/05/2006

B number: 
B360
Principal applicant name: 
Dr Carol Joinson (University of Bristol, UK)
Co-applicants: 
Dr Jon Heron (University of Bristol, UK), Prof Marcus Munafo (University of Bristol, UK), Prof Ricardo Araya (University of Bristol, UK)
Title of project: 
Cigarette Smoking and Psychopathology: Genetic and environmental effects on initiation and cessation among children and mothers in the ALSPAC cohort
Proposal summary: 

Applications are invited from suitably qualified psychology graduates to join a team investigating the development of depressive symptoms. The PhD will be undertaken in the Department of Community Based Medicine and will focus on examining the nature of the relationship between depressive symptoms and smoking.

Previous studies have found evidence for an association between depression and smoking in adolescence, but the nature and direction of the relationship is unclear. Some studies have found evidence that depressive symptoms precede the onset of smoking; others have found that smoking precedes depression, and some studies report a bi-directional relationship. The PhD student will have the opportunity to develop skills in statistical modelling of longitudinal data to model the developmental heterogeneity of depression and smoking from late childhood into adolescence and examine potential covariates including gender, behaviour and conduct problems, social adversities, stressful life events, and parent-child relationships.

The project will take advantage of the unique and extensive longitudinal data collected by ALSPAC, an ongoing longitudinal population-based study investigating a wide range of environmental and other influences on the health and development of children. Detailed information on the ALSPAC study is available on the web site: http://www.alspac.bris.ac.uk.

Data required:

Depression- Mood and feelings questionnaire (child and parent report) from 9-15 years.

Smoking- (child and parent report) from 8-15 years.

(we are aware that data from the 15/16 year questionnaire/clinic is not yet available)

Other possible data requirements: Behaviour and emotional problems- DAWBA, SDQ, antisocial behaviour questionnaire.

Social adversities and stressful life events.

Questions on parent-child relationships.

Date proposal received: 
Thursday, 18 May, 2006
Date proposal approved: 
Thursday, 18 May, 2006
Keywords: 
Depression, Environment, Genetics, Smoking
Primary keyword: 

B384 - Research Study on Potential Link between Infant Feeding and Autism - 16/05/2006

B number: 
B384
Principal applicant name: 
Dr Ethan Cohen-Cole (University of Maryland, USA)
Co-applicants: 
Title of project: 
Research Study on Potential Link between Infant Feeding and Autism.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 16 May, 2006
Date proposal approved: 
Tuesday, 16 May, 2006
Keywords: 
ADHD, Antisocial Behaviour, Autism, Diet
Primary keyword: 

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