Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

Click here to export results in Word format.

B88 - Disentangling the genetic environment and psychological determinants of eating disorders - 01/11/2001

B number: 
B88
Principal applicant name: 
Prof Janet Treasure (King's College London, UK)
Co-applicants: 
Title of project: 
Disentangling the genetic environment and psychological determinants of eating disorders.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Diet, Eating Disorder, Genetics
Primary keyword: 

B43 - Orthodontic proposal - 01/11/2001

B number: 
B43
Principal applicant name: 
A Williams (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Orthodontic proposal.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Allergies, Environmental Exposure, Respiratory, Atopy, Teeth
Primary keyword: 

B42 - Food allergy as a risk factor for severe asthma - 01/11/2001

B number: 
B42
Principal applicant name: 
Prof Gideon Lack (King's College London, UK)
Co-applicants: 
Title of project: 
Food allergy as a risk factor for severe asthma.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Allergies, Asthma, Respiratory, Atopy, Diet
Primary keyword: 

B41 - Year 3 Schools Project - 01/11/2001

B number: 
B41
Principal applicant name: 
Prof Jean Golding (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Year 3 Schools Project.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Education
Primary keyword: 

B40 - Exposure to air pollution and respiratory illness in young children - 01/11/2001

B number: 
B40
Principal applicant name: 
Prof Paul Elliott (Imperial College London, UK)
Co-applicants: 
Title of project: 
Exposure to air pollution and respiratory illness in young children.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Allergies, Environmental Exposure, Respiratory, Atopy
Primary keyword: 

B38 - The development of sex typed behaviour in boys and girls a longitudinal study from 20 weeks gestation to 12 years - 01/11/2001

B number: 
B38
Principal applicant name: 
Prof Melissa Hines (University of Cambridge, UK)
Co-applicants: 
Prof Susan Golombok (University of Cambridge, UK), Prof Jean Golding (University of Bristol, UK)
Title of project: 
The development of sex typed behaviour in boys and girls: a longitudinal study from 20 weeks gestation to 12 years.
Proposal summary: 

We propose a longitudinal, population study investigating biological and psychological processes involved in the development of gender identity, gender role behaviour and sexual orientation.

Date proposal received: 
Thursday, 1 November, 2001
Date proposal approved: 
Thursday, 1 November, 2001
Keywords: 
Puberty, Sexual Behaviour
Primary keyword: 

B288 - Maternal cholesterol during gestation Low maternal serum cholesterol in early pregnancy as a predictor of adverse birth outcome - 01/10/2001

B number: 
B288
Principal applicant name: 
Dr Maximillian Muenck (National Institute of Health Sciences, USA)
Co-applicants: 
Title of project: 
Maternal cholesterol during gestation. Low maternal serum cholesterol in early pregnancy as a predictor of adverse birth outcome.
Proposal summary: 

Cholesterol is an essential morphogenetic cofactor in developmental pathways that pattern the central nervous system during gastrulation and early embryogenesis. Adequate cholesterol is also an essential substrate for the rapid growth of neural tissues in the embryo and for synthesizing pregnancy-related steroid hormones. These critical morphogenetic events begin at embryonic day 14, prior to the establishment of a blood-brain barrier or feto-placental circulation, indicating that the embryo's early requirements may depend on uptake from the maternal circulation. Mothers with abnormally low levels of either total serum cholesterol or any essential lipoprotein fraction during the peri-conceptional period may be unable to supply the developing embryo with adequate cholesterol during this critical phase, resulting in pregnancy loss or the birth of infants with microcephaly and/or neuro-developmental disorders.

Specifically, we predict that mothers whose earliest prenatal total serum cholesterol value is within the lowest 5% of the study cohort will have an excess rate of pregnancy loss and an excess rate of microcephaly and of developmental delay in their offspring. The ALSPAC cohort is ideal for testing this hypothesis, because the number of study participants and the comprehensive pre-and post-natal data obtained from them permit an unbiased, carefully adjusted evaluation of the study hypothesis.

Date proposal received: 
Monday, 1 October, 2001
Date proposal approved: 
Monday, 1 October, 2001
Keywords: 
Birth Outcomes, Pregnancy, Nutrition
Primary keyword: 

B37 - Maternal caffeine consumption during pregnancy and reproductive outcome - 01/10/2001

B number: 
B37
Principal applicant name: 
Dr Kate Northstone (University of Bristol, UK)
Co-applicants: 
Title of project: 
Maternal caffeine consumption during pregnancy and reproductive outcome.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 October, 2001
Date proposal approved: 
Monday, 1 October, 2001
Keywords: 
Obstetrics, Pregnancy, Diet
Primary keyword: 

B36 - The impact of air pollution on early life - 01/10/2001

B number: 
B36
Principal applicant name: 
(Not used 0, Not used 0)
Co-applicants: 
Title of project: 
The impact of air pollution on early life.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 October, 2001
Date proposal approved: 
Monday, 1 October, 2001
Keywords: 
Allergies, Respiratory, Atopy, Pollution
Primary keyword: 

B35 - The demand and supply of schooling - 01/10/2001

B number: 
B35
Principal applicant name: 
Dr Leon Feinstein (University of Michigan, USA)
Co-applicants: 
Title of project: 
The demand and supply of schooling.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 October, 2001
Date proposal approved: 
Monday, 1 October, 2001
Keywords: 
Education
Primary keyword: 

B34 - The determination of affective and cognitive outcomes of primary school children in Avon - 01/10/2001

B number: 
B34
Principal applicant name: 
Dr Leon Feinstein (University of Michigan, USA)
Co-applicants: 
Title of project: 
The determination of affective and cognitive outcomes of primary school children in Avon.
Proposal summary: 

The children in the ALSPAC cohort are now entering secondary school. The work already done in establishing the dataset means that there is now a unique opportunity to study in robust, quantitative and ground-breaking terms a number of crucial issues in the educational development of UK children. These studies will have important scientific benefits and implications for current and future Government policy. However, it is necessary to move quickly if the opportunity of putting the appropriate questions to the right individuals at the right times is not to be lost.

Other data collection will be occurring in ALSPAC through this phase, particularly in the fields of psychiatry and medicine and the investments made by related funding councils and others provide a platform for investments in educational research using ALSPAC.

A particular focus of the secondary school data collection in ALSPAC will be the motivation, engagement and attainments of pupils. Data collection will also concentrate on the impact on these aspects of development of family, school, policy and wider social factors. Planned reforms to the British education system for 14-19 year olds can be monitored by their impacts on this cohort of children. Social class differences in the process of engagement, choice and attainment of pupils can also be examined and quantified.

Date proposal received: 
Monday, 1 October, 2001
Date proposal approved: 
Monday, 1 October, 2001
Keywords: 
Autism, Education, Motor Co-ordination, Neurology, Vision, Cognitive Function
Primary keyword: 

B30 - Prevalence of disability and the influence of maternal thyroid hormone levels in pregnancy - 01/09/2001

B number: 
B30
Principal applicant name: 
Dr Matthew Ellis (University of Bristol, UK)
Co-applicants: 
Title of project: 
Prevalence of disability and the influence of maternal thyroid hormone levels in pregnancy.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 September, 2001
Date proposal approved: 
Saturday, 1 September, 2001
Keywords: 
Autism, Motor Co-ordination, Neurology, Pregnancy, Thyroid, Vision, Hormones
Primary keyword: 

B9 - The genetic factors influencing the development of asthma and atopy in different European centres - 01/09/2001

B number: 
B9
Principal applicant name: 
Dr Andrea Sherriff (University of Glasgow, UK)
Co-applicants: 
Title of project: 
The genetic factors influencing the development of asthma and atopy in different European centres.
Proposal summary: 

(No proposal form received).

Date proposal received: 
Friday, 1 June, 2001
Date proposal approved: 
Saturday, 1 September, 2001
Keywords: 
Allergies, Asthma, Respiratory, Atopy
Primary keyword: 

B29 - Risk factors for obesity in contemporary children - 01/09/2001

B number: 
B29
Principal applicant name: 
Prof John Reilly (University of Strathclyde, UK)
Co-applicants: 
Dr Andrea Sherriff (University of Glasgow, UK)
Title of project: 
Risk factors for obesity in contemporary children.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 September, 2001
Date proposal approved: 
Saturday, 1 September, 2001
Keywords: 
Endocrine, Growth, Obesity, Weight
Primary keyword: 

B24 - A gene-environment study of infection susceptibility in pre-term delivery - 01/08/2001

B number: 
B24
Principal applicant name: 
Dr Mark Turner (University of Liverpool, UK)
Co-applicants: 
Title of project: 
A gene-environment study of infection susceptibility in pre-term delivery.
Proposal summary: 
Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Genetics, Infection, Obstetrics, Pregnancy, Genes, Pre term
Primary keyword: 

B22 - Cadmium exposure and renal damage in adults and children living near zinc smelter in Avonmouth - 01/08/2001

B number: 
B22
Principal applicant name: 
Dr Lars Jarup (Imperial College London, UK)
Co-applicants: 
Title of project: 
Cadmium exposure and renal damage in adults and children living near zinc smelter in Avonmouth.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Environmental Exposure
Primary keyword: 

B20 - Long-term effects of early postnatal stress - 01/08/2001

B number: 
B20
Principal applicant name: 
Dr Tom O'Connor (University of Rochester Medical Centre, USA)
Co-applicants: 
Title of project: 
Long-term effects of early postnatal stress.
Proposal summary: 

Specific aims of this research are to a) examine the long-term effects of prenatal anxiety on dimensional and diagnostic measures of psychopathology in early adolescence; b) assess the role of the HPA axis underlying the links between prenatal anxiety on adolescent psychopathology and stress vulnerability; c) test competing hypotheses concerning the processes by which prenatal anxiety has direct, mediated or moderated effects on adolescent psychopathology; and d) test the hypothesis that the effects of prenatal anxiety/stress on behavioral/emotional problems in early adolescence are moderated by genetic risk.

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Autism, Biological Samples, Depression, Mental Health, Motor Co-ordination, Neurology, Stress, Vision
Primary keyword: 

B18 - Determinants consequences of total energy expenditure and energy expended on physical activity in a representative contemporary sample of 10/11 year olds - 01/08/2001

B number: 
B18
Principal applicant name: 
Prof John Reilly (University of Strathclyde, UK)
Co-applicants: 
Title of project: 
Determinants & consequences of total energy expenditure and energy expended on physical activity in a representative contemporary sample of 10/11 year olds.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Physical Activity, Physical Fitness
Primary keyword: 

B26 - Early onset eating psychopathy - collision between satiety and constraint - 01/08/2001

B number: 
B26
Principal applicant name: 
Prof Alan Stein (University of Oxford, UK)
Co-applicants: 
Title of project: 
Early onset eating psychopathy - collision between satiety and constraint.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Diet, Eating disorders
Primary keyword: 

B25 - The SPINK gene and eczema - 01/08/2001

B number: 
B25
Principal applicant name: 
Prof Robin Callard (University College London, UK)
Co-applicants: 
Title of project: 
The SPINK gene and eczema.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 August, 2001
Date proposal approved: 
Wednesday, 1 August, 2001
Keywords: 
Eczema, Genetics, Skin, Genes
Primary keyword: 

Pages