Proposal summaries
B3559 - Does the Timing of Menarche Affect the Development of Eating Disordered Behaviour - 16/06/2020
Disordered eating behaviour remains a widespread and persistent problem among adolescent girls. The various changes associated with puberty have been implicated in the development of these behaviours (Senia 2018). The link between timing of menarche, as a proxy for pubertal development, and psychological distress more generally has been previously established (Mendle 2007, Joinson 2013). However, many questions remain about the relationship between eating disordered behaviours and pubertal development during adolescence. Previous studies have not adequately assessed the age of menarche due to recall bias. This study examines if early menarche could be relevant in the development of eating disordered behaviour using prospective measures from ALSPAC. Furthermore, this study interrogates if the link between early menarche and disordered eating behaviour holds through late adolescence, when early developersâ peers have caught up. In other words, does the association between early pubertal development and disordered eating result from the discord between a child and their peers or does it have more to do with the actual development itself?
Using questionnaire data collected through ALSPAC, this study assesses various markers relating to puberty as well as identifying timing of menarche and any disordered eating behaviour.
B3560 - Relationship between serum sclerostin and cardiovascular disease - 19/06/2020
Anti-sclerostin antibody treatment has recently been licensed as a monthly injection for treating osteoporosis (Evenity), a condition in which bones become fragile and more susceptible to fracture. Though effective at treating osteoporosis, concerns have been raised that Evenity increases the risk of developing cardiovascular disease (CVD) and stroke, either via a direct effect on arteries, or by modifying associated risk factors. This project aims to examine this question, by studying whether circulating levels of sclerostin are related to CVD end-points, related phenotypes and risk factors. This will be achieved by examining these relationships in a range of independent cohorts, including ALSPAC. Furthermore, we aim to triangulate our findings by Mendelian Randomisation, using a genetic instrument for circulating sclerostin which we recently published and are currently refining.
B3561 - Exploring how much complex trait variation is captured by DNA methylation in epigenome-wide association studies - 23/06/2020
There are small chemicals that can be added to or removed from genes. These chemical changes may be related to changes in various human traits. For example smoking may cause a decrease in the number of these chemicals present at one or many genes. Currently it is not fully understood how these chemical changes are related to changes in human traits and this project aims to assess how chemical changes across many genes may relate to changes in human traits.