Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B3559 - Does the Timing of Menarche Affect the Development of Eating Disordered Behaviour - 16/06/2020

B number: 
B3559
Principal applicant name: 
Helen Bould | University of Bristol (UK)
Co-applicants: 
Ms Sneha Nicholson, Dr Carol Joinson, Dr Jon Heron, Dr Naomi Warne
Title of project: 
Does the Timing of Menarche Affect the Development of Eating Disordered Behaviour
Proposal summary: 

Disordered eating behaviour remains a widespread and persistent problem among adolescent girls. The various changes associated with puberty have been implicated in the development of these behaviours (Senia 2018). The link between timing of menarche, as a proxy for pubertal development, and psychological distress more generally has been previously established (Mendle 2007, Joinson 2013). However, many questions remain about the relationship between eating disordered behaviours and pubertal development during adolescence. Previous studies have not adequately assessed the age of menarche due to recall bias. This study examines if early menarche could be relevant in the development of eating disordered behaviour using prospective measures from ALSPAC. Furthermore, this study interrogates if the link between early menarche and disordered eating behaviour holds through late adolescence, when early developers’ peers have caught up. In other words, does the association between early pubertal development and disordered eating result from the discord between a child and their peers or does it have more to do with the actual development itself?

Using questionnaire data collected through ALSPAC, this study assesses various markers relating to puberty as well as identifying timing of menarche and any disordered eating behaviour.

Impact of research: 
This project will lead to a greater understanding of the development of eating disorders in young adolescent girls. As eating disorders have the highest fatality of any mental health disorder, we believe this research is pertinent and salient.
Date proposal received: 
Monday, 15 June, 2020
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Eating disorders - anorexia, bulimia, Statistical methods, eating disorders; puberty

B3560 - Relationship between serum sclerostin and cardiovascular disease - 19/06/2020

B number: 
B3560
Principal applicant name: 
Jon Tobias | University of Bristol (United Kingdom)
Co-applicants: 
Monika Frysz, George Davey Smith
Title of project: 
Relationship between serum sclerostin and cardiovascular disease
Proposal summary: 

Anti-sclerostin antibody treatment has recently been licensed as a monthly injection for treating osteoporosis (Evenity), a condition in which bones become fragile and more susceptible to fracture. Though effective at treating osteoporosis, concerns have been raised that Evenity increases the risk of developing cardiovascular disease (CVD) and stroke, either via a direct effect on arteries, or by modifying associated risk factors. This project aims to examine this question, by studying whether circulating levels of sclerostin are related to CVD end-points, related phenotypes and risk factors. This will be achieved by examining these relationships in a range of independent cohorts, including ALSPAC. Furthermore, we aim to triangulate our findings by Mendelian Randomisation, using a genetic instrument for circulating sclerostin which we recently published and are currently refining.

Impact of research: 
Understanding the relationship between sclerostin and CVD risk is important in identifying patient groups in whom anti-sclerostin treatment should be used with caution. This question is particularly important as patients requiring osteoporosis treatment often have co-morbidities such as CVD due to advanced age.
Date proposal received: 
Wednesday, 17 June, 2020
Keywords: 
Epidemiology, Bone disorders - arthritis, osteoporosis, Statistical methods, Cardiovascular

B3561 - Exploring how much complex trait variation is captured by DNA methylation in epigenome-wide association studies - 23/06/2020

B number: 
B3561
Principal applicant name: 
Gibran Hemani | MRC IEU
Co-applicants: 
Mr. Thomas Battram, Professor Tom Gaunt, Professor Nicholas Timpson
Title of project: 
Exploring how much complex trait variation is captured by DNA methylation in epigenome-wide association studies
Proposal summary: 

There are small chemicals that can be added to or removed from genes. These chemical changes may be related to changes in various human traits. For example smoking may cause a decrease in the number of these chemicals present at one or many genes. Currently it is not fully understood how these chemical changes are related to changes in human traits and this project aims to assess how chemical changes across many genes may relate to changes in human traits.

Impact of research: 
Date proposal received: 
Monday, 22 June, 2020
Keywords: 
Molecular genetics and genomics, Microarrays, Epigenetics

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