Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B120 - Investigating the aetiology of chlamydia - associated with tubal factor infertility - 01/06/2003

B number: 
B120
Principal applicant name: 
Dr Nicola Low (Universitat Bern, Europe)
Co-applicants: 
Title of project: 
Investigating the aetiology of chlamydia - associated with tubal factor infertility.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 June, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Infection, Puberty, Sexual Health, Fertility/Infertility
Primary keyword: 

B119 - Neighbourhood and household influences on injuries to preschool children - 01/06/2003

B number: 
B119
Principal applicant name: 
Prof Alan Emond (University of Bristol, UK)
Co-applicants: 
Title of project: 
Neighbourhood and household influences on injuries to preschool children.
Proposal summary: 

Injuries caused by accidents are a particular problem in young children and children's injury rates vary considerably from place to place. Low-income neighbourhoods have higher child injury rates than high-income neighbourhoods, and recent research suggests that only part of the difference is due to variations in the social, economic and demographic composition of local populations. This research aims to find out the relative contributions of family characteristics and neighbourhood features to the risk of injury to children aged 0-4 years in Bristol and its surrounding region, to discover some of the mechanisms that create patterns of inequality. The objectives are:

1) to determine the risk factors acting at the level of the child, the household and the neighbourhood, and whether these risks act independently.

2) to determine whether residents' perceptions of neighbourhood and local social networks are related to geographical variations in the risk of injury.

3) to determine the size of effects and interactions between risk factors, and identify modifiable risk factors that might be subject to intervention.

4) to identify the scale (size of neighbourhoods) at which any effects of place are most evident.

Date proposal received: 
Sunday, 1 June, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Injury, Social Science, Stress, Social Conditions
Primary keyword: 

B100 - To investigate dietary patterns of children consuming high salt levels throughout early childhood - 01/06/2003

B number: 
B100
Principal applicant name: 
Dr Imogen Rogers (University of Brighton, Brighton)
Co-applicants: 
Title of project: 
To investigate dietary patterns of children consuming "high salt" levels throughout early childhood.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 March, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Diet, Eating disorders
Primary keyword: 

B118 - Expression of Interest Evidence and guidance Collaborating Centres - 01/06/2003

B number: 
B118
Principal applicant name: 
(Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Expression of Interest: Evidence and guidance Collaborating Centres.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 June, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Primary keyword: 

B117 - Methods to deal with missing data in ALSPAC - 01/06/2003

B number: 
B117
Principal applicant name: 
Prof Kate Tilling (University of Bristol, UK)
Co-applicants: 
Title of project: 
Methods to deal with missing data in ALSPAC.
Proposal summary: 

Analyses of data from longitudinal studies are often complicated by the presence of missing values, caused

by participant dropout or non-response. Failure to allow for this can lead to both biased and inefficient

statistical analyses. Analyses ignoring problems caused by missing data are common. Statistical research has

generated better ways to deal with these problems, but the methods are technically challenging. The

proposed research will focus on the application of multiple imputation (MI) - the most flexible available

method - in longitudinal studies. We will demonstrate the potential of MI to reduce bias and increase

precision in analyses of data from the ALSPAC birth cohort study and the ART-CC and ART-LINC HIV

cohort collaborations. We will also clarify the circumstances in which analyses allowing for missing data are

likely to have advantages over simpler methods. We will develop a framework for simulations that allow

evaluation of characteristics of imputation procedures, and use both simulations and analyses of longitudinal

data to examine how to deal with the model complexity that characterises application of these procedures.

We will adapt existing software to improve model diagnostics that may alert the user to problems in

imputation procedures and to facilitate sensitivity analyses that examine robustness of results to data that are

missing not at random MNAR). We will work with members of the CONSORT and STROBE groups, and

with journal editors, to provide guidelines on reporting analyses that deal with missing data.

Date proposal received: 
Sunday, 1 June, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Bones, Methodology
Primary keyword: 

B116 - Risk factors for the onset of depression in adolescence neuro-endocrine mechanisms and sex differences - 01/06/2003

B number: 
B116
Principal applicant name: 
Prof Ricardo Araya (University of Bristol, UK)
Co-applicants: 
Title of project: 
Risk factors for the onset of depression in adolescence: neuro-endocrine mechanisms and sex differences.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 June, 2003
Date proposal approved: 
Sunday, 1 June, 2003
Keywords: 
Depression, Mental Health
Primary keyword: 

B110 - Bladder and bowel continence - 01/05/2003

B number: 
B110
Principal applicant name: 
Prof Jean Golding (University of Bristol, UK)
Co-applicants: 
Title of project: 
Bladder and bowel continence.
Proposal summary: 

Generalised Growth Mixture Models will enable us to divide the children into different groups (cluster-analysis style) and fit a different trajectory for each group. In the graph below, the y-axis is the probability of being dry at night. Preliminary analysis using data up to 91 months suggests 4 different groups: normal children, delayed dryness, severely delayed dryness and a relapse group.

Group membership can then be used as either a multinomial outcome or as a predictor for further analysis into the causes/effects of subnormal development of continence. The intention is to produce one methodological paper on the subject of fitting such models and then further epidemiological papers using the resulting groups.

Date proposal received: 
Thursday, 1 May, 2003
Date proposal approved: 
Thursday, 1 May, 2003
Keywords: 
Incontinence
Primary keyword: 

B115 - Social and cultural determinants of health - 01/05/2003

B number: 
B115
Principal applicant name: 
D Baker (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Social and cultural determinants of health.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 May, 2003
Date proposal approved: 
Thursday, 1 May, 2003
Keywords: 
Social Science, Stress, Social Conditions
Primary keyword: 

B114 - Fluoride exposure and dental caries - 01/05/2003

B number: 
B114
Principal applicant name: 
A Williams (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Fluoride exposure and dental caries.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 May, 2003
Date proposal approved: 
Thursday, 1 May, 2003
Keywords: 
Environmental Exposure, Teeth
Primary keyword: 

B113 - Diet obesity and DXA - 01/05/2003

B number: 
B113
Principal applicant name: 
B Watkins (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Diet, obesity and DXA.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 May, 2002
Date proposal approved: 
Thursday, 1 May, 2003
Keywords: 
Diet, Endocrine, Growth, Obesity, Weight
Primary keyword: 

B112 - Preparation for data sharing in the large birth cohort studies - 01/05/2003

B number: 
B112
Principal applicant name: 
Prof Martha Wadsworth (Pennsylvania State University, USA)
Co-applicants: 
Title of project: 
Preparation for data sharing in the large birth cohort studies.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 May, 2003
Date proposal approved: 
Thursday, 1 May, 2003
Keywords: 
Cross Cohort Study
Primary keyword: 

B108 - Developmental predictors of early onset mood disorders - 01/04/2003

B number: 
B108
Principal applicant name: 
A Brown (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Developmental predictors of early onset mood disorders.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 April, 2003
Date proposal approved: 
Tuesday, 1 April, 2003
Keywords: 
Depression, Mental Health
Primary keyword: 

B107 - An investigation of the relationship between allergic sensitisation immunogenetic susceptibility and the risk of childhood common acute lymphoblastic leukaemia - 01/04/2003

B number: 
B107
Principal applicant name: 
Prof Malcolm Taylor (University of Birmingham, UK)
Co-applicants: 
Title of project: 
An investigation of the relationship between allergic sensitisation, immunogenetic susceptibility and the risk of childhood common acute lymphoblastic leukaemia.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 April, 2003
Date proposal approved: 
Tuesday, 1 April, 2003
Keywords: 
Allergies, Respiratory, Atopy, Cancer
Primary keyword: 

B105 - Genetic and epidemiological study of varicella infection in childhood with particular reference to the CCR5/CCR2 gene region the CC chemokine gene region the MHC III gene region the 5q31-33 gene region and IFN gamma and IF - 01/04/2003

B number: 
B105
Principal applicant name: 
J Hull (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Genetic and epidemiological study of varicella infection in childhood with particular reference to the CCR5/CCR2 gene region, the CC chemokine gene region, the MHC III gene region, the 5q31-33 gene region and IFN gamma and IFN gamma receptor gene regions.
Proposal summary: 

(No outline received).

Date proposal received: 
Tuesday, 1 April, 2003
Date proposal approved: 
Tuesday, 1 April, 2003
Keywords: 
Genetics, Infection
Primary keyword: 

B104 - Factors influencing detection and treatment of children with Attention Deficit Hyperactivity Disorder - 01/03/2003

B number: 
B104
Principal applicant name: 
Prof David Foreman (University of London, UK)
Co-applicants: 
Title of project: 
Factors influencing detection and treatment of children with Attention Deficit Hyperactivity Disorder.
Proposal summary: 
Date proposal received: 
Saturday, 1 March, 2003
Date proposal approved: 
Saturday, 1 March, 2003
Keywords: 
ADHD, Antisocial Behaviour
Primary keyword: 

B103 - A prospective cohort study of the determinants of skeletal development in childhood - 01/03/2003

B number: 
B103
Principal applicant name: 
Dr Jon Tobias (University of Bristol, UK)
Co-applicants: 
Title of project: 
A prospective cohort study of the determinants of skeletal development in childhood.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 March, 2003
Date proposal approved: 
Saturday, 1 March, 2003
Keywords: 
Bones
Primary keyword: 

B101 - Healthy eating behavioural and functional genomics of the disorders of eating - 01/03/2003

B number: 
B101
Principal applicant name: 
Prof Janet Treasure (King's College London, UK)
Co-applicants: 
Title of project: 
Healthy eating: behavioural and functional genomics of the disorders of eating.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 March, 2003
Date proposal approved: 
Saturday, 1 March, 2003
Keywords: 
Diet, Genetics, Eating disorders
Primary keyword: 

B292 - Samples for fatty acid analyses antenatal and F7 plus maternal trace metal samples for Hg analysis at CDC - 01/03/2003

B number: 
B292
Principal applicant name: 
Capt Joseph Hibbeln (National Institute of Health Sciences, USA)
Co-applicants: 
Title of project: 
Samples for fatty acid analyses (antenatal and F@7), plus maternal trace metal samples for Hg analysis at CDC.
Proposal summary: 

(No outline received).

Date proposal received: 
Wednesday, 1 January, 2003
Date proposal approved: 
Saturday, 1 March, 2003
Keywords: 
Biological Samples
Primary keyword: 

B98 - Growth in Focus - Modelling the tempo of growth in puberty and its influence on health - 01/02/2003

B number: 
B98
Principal applicant name: 
J Shield (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Growth in Focus - Modelling the tempo of growth in puberty and its influence on health.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 February, 2003
Date proposal approved: 
Saturday, 1 February, 2003
Keywords: 
Endocrine, Growth, Obesity, Puberty, Weight
Primary keyword: 

B97 - The epidemiology outcomes of psychosis-like symptoms in children - 01/02/2003

B number: 
B97
Principal applicant name: 
Prof Glynn Harrison (University of Bristol, UK)
Co-applicants: 
Prof David Gunnell (University of Bristol, UK), Prof Glyn Lewis (University of Bristol, UK), Prof Dieter Wolke (University of Warwick, UK)
Title of project: 
The epidemiology & outcomes of psychosis-like symptoms in children.
Proposal summary: 

There has been considerable recent interest in 'non-clinical' psychotic symptoms in adults and children. The Dunedin study, the only birth cohort to have investigated this, reported a prevalence of 14.1% in 11 year olds. There was a strong association (OR 16.4) between psychosis-like symptoms (PLIKS) in children and subsequent development of adult schizophreniform disorder, and PLIKS were also associated with other childhood developmental impairments. The Dunedin cohort was a relatively small (n=761) and low powered study. The 14,138 person ALSPAC birth cohort (now aged 11) presents a unique opportunity to investigate the nature, prevalence, and epidemiology of psychosis-like symptoms in childhood and adolescence.

Date proposal received: 
Saturday, 1 February, 2003
Date proposal approved: 
Saturday, 1 February, 2003
Keywords: 
Personality, PLIKS, Self-harm, Sleep, Psychosis
Primary keyword: 

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