Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

Click here to export results in Word format.

B166 - Genetic and environmental influences in speech and language development disorder - 01/05/2004

B number: 
B166
Principal applicant name: 
Prof Patrick Bolton (King's College London, UK)
Co-applicants: 
Title of project: 
Genetic and environmental influences in speech and language development & disorder.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 May, 2004
Date proposal approved: 
Saturday, 1 May, 2004
Keywords: 
Genetics, Speech & Language, Environmental
Primary keyword: 

B165 - PTHR1 - Investigation of the link between calcium homeostasis in utero and skeletal development - 01/05/2004

B number: 
B165
Principal applicant name: 
Dr Jon Tobias (University of Bristol, UK)
Co-applicants: 
Title of project: 
PTHR1 - Investigation of the link between calcium homeostasis in utero and skeletal development.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 May, 2004
Date proposal approved: 
Saturday, 1 May, 2004
Keywords: 
Biological Samples, Bones, Genetics
Primary keyword: 

B358 - Genetics of Dyslexia - 01/04/2004

B number: 
B358
Principal applicant name: 
Prof Anthony P Monaco (University of Oxford, UK)
Co-applicants: 
Title of project: 
Genetics of Dyslexia.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 April, 2004
Date proposal approved: 
Thursday, 1 April, 2004
Keywords: 
Genetics, Dyslexia
Primary keyword: 

B161 - An investigation of genetic epidemiological risk factors for psychotic-like symptoms in adolescent birth cohort - 01/04/2004

B number: 
B161
Principal applicant name: 
Dr Stanley Zammit (University of Bristol, UK)
Co-applicants: 
Title of project: 
An investigation of genetic epidemiological risk factors for psychotic-like symptoms in adolescent birth cohort.
Proposal summary: 

Objective: Toexamine genetic and environmental risk factors for developing sub-clinical, psychosis-like symptoms (PLIKS) during adolescence. Specifically:

1. To investigate whether genetic variation within NRG1, DTNBP1, DAAO, G72, RGS4 and CHRNA7 are associated with PLIKS.

2. To investigate whether cannabis or tobacco alter risk of PLIKS.

3. To examine the interplay between genetic variation and cannabis or tobacco exposure on risk of PLIKS, as well as the interplay with other risk factors for schizophrenia, including markers of neurodevelopmental abnormalities.

Background:Approximately 15% of the population report psychotic-like experiences not meeting criteria for clinical disorders. These occur more commonly than schizophrenia, and are likely to be closer to underlying aetiological pathways. Studies of PLIKS may increase understanding of schizophrenia aetiology, and help focus prevention and intervention strategies. All the genes above, as well as cannabis and tobacco, are thought to effect glutamatergic transmission. Examination of gene-environment interplay may provide further insights into aetiological mechanisms.

Design: Cohort study (nested case-control for genetic associations).

Method: The ALSPAC birth cohort of 14,000 children, currently age 11-12 will be used. Large quantities of data, including DNA, are already available. PLIKS and substance use data were collected at age 11-12 and will be re-collected at 13-14 & 15-16. Outcome to be investigated is risk of PLIKS (quantitative and dichotomous measures). Genetic analyses will include examinationunder different genetic models, haplotype analysis, and family-based association. Regressionmodels will also be used to examine association with cannabis/tobacco usewhilst adjusting for confounders, and for exploratory analysis of gene-environment interplay.

Date proposal received: 
Thursday, 1 April, 2004
Date proposal approved: 
Thursday, 1 April, 2004
Keywords: 
Genetics, Personality, PLIKS, Self-harm, Psychosis
Primary keyword: 

B142 - Environmental personal risk of accidental injury to young children in the home - 01/04/2004

B number: 
B142
Principal applicant name: 
Prof Alan Emond (University of Bristol, UK)
Co-applicants: 
Title of project: 
Environmental & personal risk of accidental injury to young children in the home.
Proposal summary: 

The aim of this proposal is to identify specific individual, psychological and environmental factors associated with child accident involvement, and to examine both their independent and interactive effects on risk-taking and injury in the home environment. The proposed study will examine these effects both cross-sectioally and longitudinally in a contemporary representative sample - the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.

Date proposal received: 
Thursday, 1 January, 2004
Date proposal approved: 
Thursday, 1 April, 2004
Keywords: 
Environmental Exposure, Injury
Primary keyword: 

B159 - Factor V Leiden and adverse pregnancy outcome - 01/03/2004

B number: 
B159
Principal applicant name: 
Dr Tracy Dudding (University of Newcastle, ROW)
Co-applicants: 
Prof Rodney Scott (University of Newcastle, ROW), Dr John Attia (University of Newcastle, ROW)
Title of project: 
Factor V Leiden and adverse pregnancy outcome.
Proposal summary: 

The aetiology of adverse pregnancy outcomes such as pre-eclampsia and fetal growth retardation is likely to be multifactorial and influenced by a complex interplay between maternal, fetal and placental factors. Given that a successful pregnancy outcome is highly dependent on the establishment and maintenance of an adequate placental circulation, it is possible that abnormalities of placental vasculature, leading to inadequate fetomaternal circulation, may be responsible for at least some poor pregnancy outcomes. This has led to an interest in the thrombophilias as risk factors for adverse pregnancy outcome. The factor V Leiden mutation is the most common form of inherited thrombophilia.1 A point mutation in the factor V gene at nucleotide position 1691, resulting in an arginine to glutamine substitution, reduces the sensitivity of the factor V protein to inactivation by activated protein C (activated protein C resistance) resulting in a pro-coagulant state and an increased risk of thrombosis.2 The trait is inherited in an autosomal dominant manner with the risk of thrombosis increased seven times in heterozygotes and 80 times in homozygotes. 3 Studies have shown that the distribution of the factor V Leiden mutation varies in different populations, being present in about 5% of Caucasian individuals (Europeans, Jews, Arabs and Indians) and virtually absent in Africans and Asians.

Rey et al 2003 published a meta-analysis confirming the association between recurrent fetal loss and the factor V Leiden mutation.4 Rai et al 2002 aimed to tease out the isolated contribution of factor V Leiden by comparing FVL+ women with recurrent fetal loss to FVL- women with the same history of fetal loss. The live birth rate was significantly lower among the women who carried the mutation confirming that factor V Leiden independently increases the risk of fetal loss.5 Data from our recently published meta-analysis concludes that factor V Leiden is also associated with a 2.9 fold (95%CI 2.0-4.3) increased risk of severe pre-eclampsia and a 4.8 fold (95% CI 2.4-9.4) increased risk of fetal growth retardation6.

A function enhancing mutation in the Prothrombin gene (Prothrombin G20210A) results in higher circulating levels of prothrombin, the precursor of thrombin. This mutation is present in 2.3 % of the general population is associated with a 3-4 fold increased risk of thromboembolism. The Leiden thrombophilia study reported a relative risk of 2.8 with the 20210A Prothrombin gene variant in 2.3% of healthy carriers and 6.2% of consecutive controls.

A meta-analysis with pooled data from nine studies (n=2087) indicated a significant association between the prothrombin G20210A mutation with late non-recurrent fetal loss (2.30,1.09-4.87) 4 A number of small case-control studies have conflicting results with respect to a possible association between prothrombin and the risk of pre-eclampsia and intrauterine growth restriction; and larger prospective studies are needed to clarify a possible relationship. There have been no studies evaluating a possible risk of adverse pregnancy outcome associated with the fetal Prothrombin G20210A mutation.

Most of the research in this area has been in the form of case-control studies which are notoriously subject to bias. We are therefore proposing a nested case-control study, which is methodologically more vigorous.

Placental thrombi resulting in placental infarction may occur on either side of the maternal-fetal interface, and theoretically the fetal as well as the maternal factor V Leiden genotype may influence the risk of adverse pregnancy outcome. Therefore, we aim to address the effect, not only of maternal factor V Leiden and prothrombin G20210A mutation, but also of fetal factor V Leiden and prothrombin G20210A mutation on pre-eclampsia, intrauterine growth retardation and late fetal death.

1 Rosendaal F. Thrombosis Series: Venous thrombosis: a multi causal disease. Lancet 1993;353:1167-73.

2 Bertina R, Koelenan B, Koster T, Rosendall FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:65-67.

3 Spina V, Aleandri V, Morini F. The impact of Factor V Leiden on pregnacy. Hum Reprod Update 2000;6: 301-306.

4 Rey E, Kahn S, David M, Shier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361:901-908.

5 Rai R, Backos M, Elgaddal S, Shlebak A, Regan L. Factor V leiden and recurrent miscarriage-prospective outcome of untreated pregnancies. Human Reproduction 2002;17:442-445.

6 Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V ledien genotype: a meta-analysis. Thromb Haemost 2004;91:700-11.

Date proposal received: 
Monday, 1 March, 2004
Date proposal approved: 
Monday, 1 March, 2004
Keywords: 
Genetics, Obstetrics, Pregnancy
Primary keyword: 

B154 - Selective assessment of colour motion and contrast acuity in the ALSPAC study - 01/03/2004

B number: 
B154
Principal applicant name: 
Miss Cathy E M Williams (University of Bristol, UK)
Co-applicants: 
Title of project: 
Selective assessment of colour, motion and contrast acuity in the ALSPAC study.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 March, 2004
Date proposal approved: 
Monday, 1 March, 2004
Keywords: 
Autism, Motor Co-ordination, Neurology, Vision
Primary keyword: 

B152 - Childhood viral infections - 01/02/2004

B number: 
B152
Principal applicant name: 
Prof Judith Breuer (University College London, UK)
Co-applicants: 
Title of project: 
Childhood viral infections.
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 February, 2004
Date proposal approved: 
Sunday, 1 February, 2004
Keywords: 
Infection
Primary keyword: 

B151 - Are higher levels of physical activity in pregnant women associated with better mental health before and after children - 01/02/2004

B number: 
B151
Principal applicant name: 
Dr Judith Ibison (University of London, UK)
Co-applicants: 
Title of project: 
Are higher levels of physical activity in pregnant women associated with better mental health before and after children?
Proposal summary: 

(No outline received).

Date proposal received: 
Sunday, 1 February, 2004
Date proposal approved: 
Sunday, 1 February, 2004
Keywords: 
Depression, Mental Health, Physical Activity, Physical Fitness, Pregnancy
Primary keyword: 

B144 - Investigation of the role of calcium homeostasis in the programming of bone development by early life factors - 01/01/2004

B number: 
B144
Principal applicant name: 
Dr Jon Tobias (University of Bristol, UK)
Co-applicants: 
Title of project: 
Investigation of the role of calcium homeostasis in the programming of bone development by early life factors.
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 January, 2004
Date proposal approved: 
Thursday, 1 January, 2004
Keywords: 
Bones
Primary keyword: 

B143 - A life course study on the cause of obesity and its co-morbidities OBESGEN - 01/01/2004

B number: 
B143
Principal applicant name: 
Mr Mike Crawford (University of Bristol, UK)
Co-applicants: 
Title of project: 
A life course study on the cause of obesity and its co-morbidities (OBESGEN).
Proposal summary: 

(No outline received).

Date proposal received: 
Thursday, 1 January, 2004
Date proposal approved: 
Thursday, 1 January, 2004
Keywords: 
Endocrine, Growth, Obesity, Weight
Primary keyword: 

B149 - ESRC - Centre for Public Organisation - 01/12/2003

B number: 
B149
Principal applicant name: 
Prof Simon Burgess (University of Bristol, UK)
Co-applicants: 
Title of project: 
ESRC - Centre for Public Organisation.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 December, 2003
Date proposal approved: 
Monday, 1 December, 2003
Keywords: 
Social Science, Stress, Social Conditions
Primary keyword: 

B141 - A large scale study of the impact of speech language abilities on psychological development in adolescence - 01/12/2003

B number: 
B141
Principal applicant name: 
Dr Judy Clegg (University of Sheffield, UK)
Co-applicants: 
Title of project: 
A large scale study of the impact of speech & language abilities on psychological development in adolescence.
Proposal summary: 

(No outline received).

Date proposal received: 
Monday, 1 December, 2003
Date proposal approved: 
Monday, 1 December, 2003
Keywords: 
Speech & Language
Primary keyword: 

B140 - EARNEST - 01/12/2003

B number: 
B140
Principal applicant name: 
Dr Margaret Ashwell (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
EARNEST.
Proposal summary: 

The idea that nutrition in early life (foetal and infant) influences or 'programmes' long term health outcomes

has major implications for human biology, public health practice, inequalities in health and policy

development as well as for product development and wealth creation.

The scientific objectives of EARNEST with an indication of which THEMES will contribute to their

achievement are listed below.

* Quantification of the effects of early programming on later cardiovascular diseases, obesity, diabetes,

cognitive and mental disorders, bone health and some cancers (Themes 1-3)

* Definition of the relative importance of critical periods in foetal and early life on later disease (1-3)

Exploration of the impact of genetic determinants on early programming effects and on subsequent

outcome (3)

* Understanding the role of specific nutrients and their interactions in the maternal and infant diet on

programming effects on disease and their risk factors (1-3)

* Understanding mechanisms for early programming on later disease and their risk factors (3)

* Development of appropriate strategies for treating and especially for preventing the amplification of

adverse programming effects of early nutrition (1)

* Exploration of the public health impact of how knowledge about early programming affects consumer

behaviour (4)

* Quantification of the impact of early nutrition on the economic burden of adult ill-health (5)

* Improvement of training and enhancement of training opportunities for all including accession countries

(8)

Objectives are given in a broad sense for the themes, more specifically for the included workpackages and

for the individual activitiesm wherever possible and meaningful.

Date proposal received: 
Monday, 1 December, 2003
Date proposal approved: 
Monday, 1 December, 2003
Keywords: 
Cardiovascular , Endocrine, Growth, Obesity, Weight
Primary keyword: 

B162 - The prevalence and co-morbidity of autism spectrum disorders - 01/11/2003

B number: 
B162
Principal applicant name: 
Prof David Skuse (University College London, UK)
Co-applicants: 
Title of project: 
The prevalence and co-morbidity of autism spectrum disorders.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Autism, Motor Co-ordination, Neurology, Vision
Primary keyword: 

B134 - Cognitive behavioural educational outcomes of children who have been bereaved - 01/11/2003

B number: 
B134
Principal applicant name: 
S Brown (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
Cognitive, behavioural & educational outcomes of children who have been bereaved.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Autism, Education, Motor Co-ordination, Neurology, Vision, Behavioural Problems, Cognitive Function
Primary keyword: 

B138 - The Avon Secondary Schools Project - 01/11/2003

B number: 
B138
Principal applicant name: 
Dr Leon Feinstein (Not used 0, Not used 0)
Co-applicants: 
Title of project: 
The Avon Secondary Schools Project.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Education
Primary keyword: 

B137 - The role of nutrition and paracetamol exposure in the aetiology of asthma - 01/11/2003

B number: 
B137
Principal applicant name: 
Prof Seif Shaheen (Queen Mary, University of London, UK)
Co-applicants: 
Title of project: 
The role of nutrition and paracetamol exposure in the aetiology of asthma.
Proposal summary: 

As part of our analyses of prenatal nutrition we plan to analyse the effects of prenatal alcohol exposure on childhood atopic outcomes. We propose, in addition to analysing the maternal questionnaire data on alcohol intake, to utilise a Mendelian randomisation approach in order to remove potential bias and confounding and add rigour. We would like to analyse the maternal ADH1B variant (data requested) which has been shown to predict alcohol intake in pregnancy in ALSPAC. A DTA covering analysis of genetic data is already in place with QMUL. We have all other variables (maternal exposure, confounders and childhood atopic outcomes) needed to carry out these analyses.

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Allergies, Respiratory, Atopy, Drugs, Nutrition
Primary keyword: 

B163 - The influence of environmental factors on hip structure in childhood - 01/11/2003

B number: 
B163
Principal applicant name: 
Dr Jon Tobias (University of Bristol, UK)
Co-applicants: 
Title of project: 
The influence of environmental factors on hip structure in childhood.
Proposal summary: 

This project aims to identify major environmental influences on hip structure in childhood, by testing hypotheses for how expansion of the inner and outer surfaces of the hip bone is controlled during growth. This will be achieved by exploiting the unique Avon and Longitudinal Study of Parents and Children (ALSPAC) birth cohort, in which children born in Avon between 1991-2 have been followed up in detail since before birth. We will investigate the relationship between environmental factors recorded in ALSPAC, and hip structure as assessed at age 13 using a low energy x-ray technique. By improving our understanding of the deterimants of hip structure in this way, the present proposal is intended to shed light on the childhood origins of hip fracture in later life, and provide a basis for population-based strategies aimed at reducing the prevalence of this common condition.

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Bones, Environmental
Primary keyword: 

B135 - NAC Fellowship - 01/11/2003

B number: 
B135
Principal applicant name: 
Prof Miriam Moffatt (Imperial College London, UK)
Co-applicants: 
Title of project: 
NAC Fellowship.
Proposal summary: 

(No outline received).

Date proposal received: 
Saturday, 1 November, 2003
Date proposal approved: 
Saturday, 1 November, 2003
Keywords: 
Allergies, Genetics, Respiratory, Atopy
Primary keyword: 

Pages