B4763 - Epidemiology and aetiology of Avoidant Restrictive Food Intake Disorder - 19/12/2024

B number: 
B4763
Principal applicant name: 
Samuel Chawner | Centre for Neuropsychiatric Genetics & Genomics, Cardiff University School of Medicine (United Kingdom)
Co-applicants: 
Dr Peter Richardson
Title of project: 
Epidemiology and aetiology of Avoidant Restrictive Food Intake Disorder
Proposal summary: 

Avoidant Restrictive Food Intake Disorder (ARFID) is a severe eating disorder that causes people to avoid certain foods or limit their intake. Unlike other eating disorders, ARFID isn’t about body image—it can stem from low appetite, sensory sensitivity to textures and smells, or a fear of choking or vomiting. Affecting around 1–2% of the population, ARFID can lead to malnutrition, health complications, and significant distress.
Our research focuses on understanding ARFID’s causes and how it varies between individuals. We aim to answer big questions: Is ARFID primarily a neurodevelopmental condition, an anxiety disorder, or influenced by physical health issues? Are there distinct subtypes of ARFID requiring different treatments? What are the genetic, environmental, and developmental risk factors for ARFID, and do these differ by subtype?
To explore these questions, we will analyse ALSPAC data, alongside data from the Norwegian MoBa cohort and the Born in Bradford cohort, and work closely with people living with ARFID, healthcare providers, and the eating disorder charity Beat. By involving those with lived experience at every stage, we will ensure our findings are relevant and impactful.
This project will help identify new approaches to diagnosing and treating ARFID, creating evidence-based tools for clinicians and improving support for those affected. With ARFID research in its early stages, this work is crucial to advancing our understanding and shaping better services.
Our goal is to bring real-world benefits to individuals and families struggling with ARFID, ensuring they receive the care and support they need.

Impact of research: 
The likely impact of this research will be transformative for the understanding and management of Avoidant Restrictive Food Intake Disorder (ARFID). By characterising the clinical heterogeneity of ARFID and identifying distinct subtypes, this work will provide a foundation for more precise and effective diagnostic criteria. Insights into the genetic and environmental factors driving ARFID will advance our understanding of its underlying causes, paving the way for personalised intervention strategies. Furthermore, the research will inform evidence-based service guidelines and resources, improving the support available for individuals and families affected by ARFID. Through co-production with people with lived experience, the findings will be directly relevant to their needs, influencing both clinical practice and public health policy to enhance early identification and treatment of ARFID.
Date proposal received: 
Sunday, 1 December, 2024
Date proposal approved: 
Monday, 2 December, 2024
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Eating disorders - anorexia, bulimia, Computer simulations/modelling/algorithms, DNA sequencing, GWAS, Metabolomics, Statistical methods, Birth outcomes, BMI, Nutrition - breast feeding, diet, Parenting, Childhood - childcare, childhood adversity, Development, Environment - enviromental exposure, pollution, Genetic epidemiology, Genetics, Genomics, Genome wide association study, Metabolic - metabolism