B4770 - Exploring Transdiagnostic Trajectories in Youth Mental Health The Role of the Genome and Exposome - 06/12/2024

B number: 
B4770
Principal applicant name: 
Sinan Guloksuz | Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University (The Netherlands)
Co-applicants: 
Angelo Arias Magnasco, MSc, Dr. Lotta-Katrin Pries, Dr. Bochao Danae Lin
Title of project: 
Exploring Transdiagnostic Trajectories in Youth Mental Health: The Role of the Genome and Exposome
Proposal summary: 

This project aims to improve our understanding of how mental health conditions emerge and develop during childhood, adolescence and early adulthood. By studying the interplay between biological and environmental factors, we aim to uncover how these influences can either contribute to drive or prevent the onset of mental ill-health. This research is part of the Youth-GEMs project, a European consortium dedicated to investigating gene-environment interactions in the mental health trajectories of young people (ALSPAC proposal B3879).

Impact of research: 
This project is expected to have a significant impact across multiple domains: scientific research, clinical practice, and policy-making. By creating an accessible knowledge platform, it will enhance our understanding of mental health and illness trajectories during critical developmental stages. The project will also contribute to the development of robust prediction tools for early intervention, enabling improved healthcare for young people. Ultimately, this work aims to reduce suffering, disability, and the socioeconomic consequences of mental health disorders, fostering a healthier and more resilient society.
Date proposal received: 
Thursday, 5 December, 2024
Date proposal approved: 
Friday, 6 December, 2024
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Mental health, Statistical methods, Environment - enviromental exposure, pollution, Genetic epidemiology