This study constructs an epigenetic clock for pregnant women based on placental DNA methylation information, addressing the applicability gap of traditional methods for estimating epigenetic age in the pregnant population and improving the accuracy and specificity of such estimates. By incorporating the actual age of the mother, her epigenetic age, and the accelerated epigenetic age (the residual difference between epigenetic age and actual age) into a unified analytical framework, this research explores how these factors jointly influence the reproductive and developmental processes of the offspring, providing new insights and methods for predicting and optimizing the healthy development of the offspring. Through in-depth investigation of the intrinsic relationship between maternal epigenetic age and offspring reproductive development, the study uncovers the epigenetic mechanisms underlying the mother-fetus interaction, offering scientific evidence and potential intervention targets for optimizing maternal and infant health management, preventing birth defects, and promoting the healthy growth of the offspring. This work is expected to guide clinical practice in the field of maternal and infant health in the future.