B4374 - Parental-related risk factors for central nervous system disorder - 18/11/2024

B number: 
B4374
Principal applicant name: 
Quan Cheng | Department of Neurosurgery, Xiangya Hospital, Central South University (China)
Co-applicants: 
Dr. Chunrun Qu, Dr. Jie Wen, Dr. Zhixiong Liu, Dr. Hao Zhang, Dr. Gaoyuan Cui, Dr. Ziyu Dai, Dr. Wanyao Liu, Dr. Jingwei Zhang, Dr. Zhuoyi Liu, Dr. Yuchen Wang
Title of project: 
Parental-related risk factors for central nervous system disorder
Proposal summary: 

Both functional and organic disorders of the central nervous system (CNS) can cause serious physical harm and emotional distress to patients. Previous research suggests that parent-related factors may be associated with CNS disorders in the population, and in this project we have focused on the genetic factors of both parents, the physical condition of the pregnant woman before and after pregnancy, and the level of health care she receives. Using the ALSPAC data, we hope to further identify specific factors and quantify the strength of their influence.

Impact of research: 
We hope that the results are suitable for writing for peer-reviewed publication. This study will clarify the specific effects of parent-related factors on central nervous system disorders, providing evidence for the prevention of central nervous system disorders and improving patient prognosis.
Date proposal received: 
Saturday, 18 May, 2024
Date proposal approved: 
Monday, 18 November, 2024
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Cancer, Cognitive impairment, Congenital abnormalities, Epilepsy, Learning difficulty, Mental health, Computer simulations/modelling/algorithms, GWAS, Statistical methods, Whole genome sequencing