B4601 - Interrogating the age-dependent genetic architecture of childhood BMI using a novel longitudinal GWAS framework - 08/05/2024
B number:
B4601
Principal applicant name:
Hélène Ruffieux | MRC Biostatistics Unit, University of Cambridge
Co-applicants:
Dr Daniel Temko
Title of project:
Interrogating the age-dependent genetic architecture of childhood BMI using a novel longitudinal GWAS framework
Proposal summary:
Understanding how the influence of genes on BMI changes over the course of childhood holds important implications for understanding why BMI differs between children of different ages, and, ultimately, for understanding the biological basis of some adult diseases. We have recently developed an approach for interrogating longitudinal data along with genetic data to glean insights into genetic effects on health trajectories. In this project, we seek to understand whether the approach we have developed can help to clarify the age-varying effects of genes on BMI in childhood.
Impact of research:
The likely impact of the research will be to provide information on the performance of our longitudinal GWAS approach on an application of broad biomedical interest. The research also has the potential to identify novel loci linked to childhood BMI trajectories and to inform understanding of the effects of loci that have already been identified.
Date proposal received:
Friday, 26 April, 2024
Date proposal approved:
Monday, 29 April, 2024
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Diabetes, Obesity, GWAS, Statistical methods, BMI, Cardiovascular, Development, Genetics, Genomics, Genome wide association study, Growth, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Statistical methods