B4580 - Maternal depression during pregnancy and child neurodevelopment and mental health outcomes - 17/04/2024

B number: 
B4580
Principal applicant name: 
Hanan El Marroun | Erasmus MC (Netherlands)
Co-applicants: 
Miss Jana Hermans, Dr. Charlotte Cecil
Title of project: 
Maternal depression during pregnancy and child neurodevelopment and mental health outcomes.
Proposal summary: 

Prenatal depression presents a burden and potential risks for the expecting women (Chung et al., 2001; Kim et al. 2013) and may have long-term consequences for the child regarding their cognitive, behavioural, and emotional development (Madigan et al., 2018; Rogers et al., 2020). However, there is a lack of large-scale studies investigating the relationship between prenatal maternal depression and child behavioural and emotional development that control for a common set of relevant potential confounding variables. In this project, we aim to study the effects of prenatal maternal depression on children’s long-term behavioural development and mental health, leveraging large-scale, multi-cohort data in the EU Child Cohort Network. As a secondary objective, we plan to disentangle the effects of pre-pregnancy, prenatal and postnatal depression on offspring development. The strength that comes with studying this research question in the LifeCycle cohort is the large amount of harmonised, multi-cohort data available, which allows us to investigate offspring outcomes over time while also controlling for relevant confounding factors. Furthermore, rather than focusing on a single behavioural outcome, our approach will be comprehensive in that it will examine a range of measures including cognition, internalising and externalising behaviour, and autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). This can aid our understanding of symptom profiles for children prenatally exposed to maternal depression.

Impact of research: 
This research will give insight into the prospective associations between exposure to prenatal maternal depression and cognitive and child mental health outcomes. This objective will be studied comprehensively by leveraging large-scale, multi-cohort data in the EU Child Cohort Network. Furthermore this project could disentangle the effects of pre-pregnancy, prenatal and postnatal depression on offspring development.
Date proposal received: 
Monday, 15 April, 2024
Date proposal approved: 
Wednesday, 17 April, 2024
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Mental health, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Speech/language problem, Statistical methods, Cognition - cognitive function, Development, Offspring, Speech and language