Prenatal Alcohol Exposure (PAE) can lead to problems with learning and behaviour, as well as physical abnormalities including distinctive facial features and stunted growth. Existing studies have identified some associations between PAE and a wide variety of other abnormalities including various musculoskeletal (MSK) disorders. Studies on the MSK effects of prenatal alcohol exposure in mice have replicated this finding and found that males were more affected by PAE than females. This has yet to be studied in human participants. Our study seeks to estimate the association between PAE and MSK abnormalities among participants enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC), and assess whether these effects differ between males and females.