B4575 - Adverse health outcomes in offspring following in utero exposure to maternal medication - 12/04/2024

B number: 
B4575
Principal applicant name: 
Michael Fleming | School of Health and Wellbeing, University of Glasgow. (United Kingdom)
Co-applicants: 
Ahmed Aldakhil, Professor Daniel Mackay, Professor Jill Pell
Title of project: 
Adverse health outcomes in offspring following in utero exposure to maternal medication
Proposal summary: 

Pregnancy is a vulnerable period when the foetus undergoes rapid development; therefore, exposure to adverse risk factors can have lifelong implications. Use of medicines during pregnancy is avoided where possible but is sometimes unavoidable. Whilst acute adverse effects following foetal exposure in utero have been assessed for several medicines, possible longer-term effects are not well understood. In particular, their effect on dental and oral outcomes is poorly understood. Using ALSPAC health data will enable us to do novel research to improve our understanding of the effects of taking medication during pregnancy on the child’s oral and dental health and development.

Impact of research: 
Demonstration of adverse associations or failure to demonstrate adverse associations would both be informative to clinicians and pregnant women in terms of caution or reassurance regarding use of the specific drugs during pregnancy.
Date proposal received: 
Wednesday, 20 March, 2024
Date proposal approved: 
Wednesday, 27 March, 2024
Keywords: 
Epidemiology, Congenital abnormalities, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Statistical methods, Birth outcomes, Development, Dental, Growth, Offspring, Statistical methods