B4578 - Genome-Wide Association Study of Blood Pressure and the influence of education - 26/03/2024

B number: 
Principal applicant name: 
Marisa Canadas Garre | University of Bristol (United Kingdom)
Professor Nicholas Timpson, Dr Laura Corbin
Title of project: 
Genome-Wide Association Study of Blood Pressure and the influence of education
Proposal summary: 

The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium is an international organization founded to facilitate large-scale genetic studies among multiple large and well-characterised groups of participants.

The goal of the CHARGE studies is to identify susceptibility genes involved in diseases of the heart, lung, and blood and their risk factors.
In our study, we will analyse the association of gene variants with blood pressure, considering the effect of the educational level in ALSPAC participants. The results will be combined with results from other groups of participants around the world to be able to identify new gene variants that help understand the biology of blood pressure.

Impact of research: 
Greater understanding of the aetiology of blood pressure. This study will help identify novel genetic variants involved in blood pressure and how genetic variants affect these traits considering potential interactions with educational attainment.
Date proposal received: 
Friday, 22 March, 2024
Date proposal approved: 
Tuesday, 26 March, 2024
Genetic epidemiology (including association studies and mendelian randomisation), Hypertension, Obesity, Computer simulations/modelling/algorithms, Gene mapping, GWAS, Metabolomics, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Statistical methods, Blood pressure, BMI, Cardiovascular, Cohort studies - attrition, bias, participant engagement, ethics, Genetic epidemiology, Genetics, Genomics, Genome wide association study