B4542 - Identifying markers for brain signatures of adolescent depression and depression risk - part 2 - 20/02/2024

B number: 
B4542
Principal applicant name: 
Alex Kwong | MRC IEU / University of Edinburgh
Co-applicants: 
Ms Christina Steyn
Title of project: 
Identifying markers for brain signatures of adolescent depression and depression risk - part 2
Proposal summary: 

We are requesting permission for a PhD rotation student to analyse existing data that is held at the University of Edinburgh under the proposal B3860. We do not require any more data, only to allow the student access to this data so they can replicate some analysis that has been done in Generation Scotland.

B3860 is examining: investigating the brain signatures of
adolescent depression and depression risk. In order to fully examine this project,
we are running some initial analysis to define the most robust markers of
depression across adolescence. From preliminary analysis and other research, we
have found that trajectories of depressive symptoms may be robust markers for
some brain signatures. Additionally, these trajectories could mediate the
relationship between early risk factors and later brain signatures.

Impact of research: 
Date proposal received: 
Friday, 16 February, 2024
Date proposal approved: 
Tuesday, 20 February, 2024
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Mental health, Statistical methods, Genetic epidemiology