B4538 - Genome-Wide Association Study of Lipid Traits and the influence of Body-Mass Index and Age - 20/02/2024
B number:
B4538
Principal applicant name:
Marisa Canadas Garre | University of Bristol (United Kingdom)
Co-applicants:
Professor Nicholas Timpson, Dr Laura Corbin
Title of project:
Genome-Wide Association Study of Lipid Traits and the influence of Body-Mass Index and Age
Proposal summary:
The Global Lipids Genetics Consortium (GLGC) is a world-wide collaboration of investigators dedicated to understanding how the different variants in genes can influence the blood levels of lipid traits, such as cholesterol, triglycerides, etc. In our study, we will analyse the association of gene variants with blood lipid levels, considering the effect of age and body-mass index in ALSPAC participants. The results will be combined with results from other groups of participants around the world to be able to identify new gene variants that help understand the biology of blood lipid traits.
Impact of research:
Greater understanding of the aetiology of blood lipids. This study will help identify novel genetic variants involved in lipid traits and how genetic variants affect these traits considering potential interactions with either BMI or age.
Date proposal received:
Friday, 9 February, 2024
Date proposal approved:
Tuesday, 20 February, 2024
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Hypertension, Obesity, Hypercholesterolemia, Computer simulations/modelling/algorithms, Gene mapping, GWAS, Metabolomics, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Statistical methods, Blood pressure, BMI, Cardiovascular, Genetic epidemiology, Genetics, Genomics, Genome wide association study, Metabolic - metabolism