B4413 - Building blocks of cognition The co-development of brain function and cognition across the first 5 years of life - 13/02/2024

B number: 
B4413
Principal applicant name: 
Karla Holmboe | University of Bristol (United Kingdom)
Co-applicants: 
Prof. Mara Cercignani, Dr. Zsofia Nemoda
Title of project: 
Building blocks of cognition: The co-development of brain function and cognition across the first 5 years of life
Proposal summary: 

The first 5 years of life is a key period of development – not only do children grow at the fastest rate in their lifetime, they also develop a vast range of new skills and abilities. In this study, we are interested in some of the most important skills that children develop during this period, including language skills, the ability to quickly understand and react to new information, and the ability to concentrate and adjust behaviour in everyday life. Alongside this, we are interested in how the brain develops and allows children to learn all these new things, and, in turn, how new experiences may lead to changes in the brain. To do this, we will see the same children in the lab for assessments at multiple time points between 6 months and 5 years. Participating families will be recruited from the ALSPAC sample, meaning that the study children’s parents (i.e., the ‘Children of the 90s’) will already have participated in many assessments themselves (since their own childhood). This gives us useful information about the parents and their background, which will help us understand more about how their children develop. At the final time point (when children are 5 years old), we will look at how development of the brain and the key cognitive skills prepare children to start school, with the ultimate aim of understanding more about why some children struggle in school, either academically and/or socially.

Impact of research: 
The over-arching aim of my research is to understand the early developmental pathways (at both the biological/neural and behavioural levels) that lead to some children struggling in school. I have taken the approach of investigating this question in typically developing children (instead of ‘at risk’ children) because even in this group there is a full spectrum of outcomes – from children who easily transition and thrive in school to children who really struggle. It seems likely that the development of key skills and abilities before the school years play a significant role preparing the child for the requirements of school (e.g., ability to pick up new information, concentration skills, language skills). Unfortunately, we know that children who struggle in the early years often continue to struggle throughout the school years and into adulthood. Therefore, in the long term, knowing the factors that lead to difficulties at school start may allow us to better support children at the earliest possible age, which I hope will lead to better outcomes during the school years and beyond.
Date proposal received: 
Wednesday, 6 September, 2023
Date proposal approved: 
Monday, 11 September, 2023
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Learning difficulty, Mental health, Speech/language problem, Cognitive development across the typical and atypical spectrum; Struggling in school, Medical imaging, Microarrays, Statistical methods, Neuroimaging, physiological measures, behavioural testing, executive functions, language skills, cognitive development