B4482 - Epigenome-wide DNA methylation associations with mental health and brain structure - 22/01/2024

B number: 
Principal applicant name: 
Sylvane Desrivieres | King's College London
Xinyang Yu
Title of project: 
Epigenome-wide DNA methylation associations with mental health and brain structure
Proposal summary: 

Adolescence is the age of onset of many common mental disorders. The roles of epigenetic modifications, such as DNA methylation (DNAm), has increasingly been recognised in neurological and psychiatric disorders, brain development, and aging. Investigating the relationships between DNAm and mental health, particularly in children and adolescents, is crucial for identifying early biomarkers and for enhancing our understanding of biological mechanisms underlying risk for and onset of mental illness at this developmentally sensitive period.

Impact of research: 
This work will identify and validate blood-based DNAm biomarkers and related genes that are crucial for pubertal development, mental disorders, and brain development, aiming to provide targets for early interventions. High impact publications and conference presentations will be expected from this research.
Date proposal received: 
Sunday, 3 December, 2023
Date proposal approved: 
Wednesday, 6 December, 2023
Mental health - Psychology, Psychiatry, Cognition, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Eating disorders - anorexia, bulimia, Mental health, GWAS, Microarrays, RNA, Statistical methods, Ageing, BMI, Cognition - cognitive function, Development, Equipment - MRI, Environment - enviromental exposure, pollution, Epigenetics, Expression, Psychology - personality, Statistical methods