B4481 - Examining the role of inflammation in the heterogeneity of depression - 18/12/2023

B number: 
B4481
Principal applicant name: 
Holly Fraser | MRC IEU
Co-applicants: 
Professor Golam Khandaker, Dr Nick Donnelly
Title of project: 
Examining the role of inflammation in the heterogeneity of depression
Proposal summary: 

This project will look at the role of the immune system in mental health in the ALSPAC population. This is being done to discover whether inflammation plays a role in mental health, and if so, what sort of treatments could be developed to help treat depression.

Impact of research: 
This research will contribute to an enhanced understanding of drivers of heterogeneity in the clinical population. Novel pharmacological strategies for depression treatment may also be informed by this work.
Date proposal received: 
Tuesday, 5 December, 2023
Date proposal approved: 
Monday, 18 December, 2023
Keywords: 
Epidemiology, Mental health, Machine learning, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc.