B4476 - DNA methylation proxy of alcohol intake - 01/12/2023

B number: 
Principal applicant name: 
Matthew Suderman | IEU, University of Bristol (UK)
Professor Riccardo Marioni, Aleksandra Chybowska
Title of project: 
DNA methylation proxy of alcohol intake
Proposal summary: 

DNA methylation patterns in blood samples are known to be influenced by a variety of exposures including lifestyle factors including smoking, alcohol consumption and diet. Although many of these exposures can be reasonably accurately assessed by self-report questionnaire, there are significant advantages to having objective measures of these exposures using biological samples over self-report which is known to be unreliable, especially for long-term exposures. We therefore propose to construct and validate an accurate DNA methylation-based model of long-term alcohol intake using data from a large number of cohort studies including ALSPAC.

Impact of research: 
The alcohol intake DNA methylation model will allow researchers to objectively assess long-term alcohol consumption behaviors to better understand the causes and effects of alcohol consumption.
Date proposal received: 
Wednesday, 29 November, 2023
Date proposal approved: 
Friday, 1 December, 2023
Epidemiology, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Microarrays, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Epigenetics