B4466 - Developmental trajectories in people born after assisted reproductive technology - 01/12/2023

B number: 
Principal applicant name: 
Ahmed Elhakeem | MRC IEU (UK)
Title of project: 
Developmental trajectories in people born after assisted reproductive technology
Proposal summary: 

This project aims to understand the long-term developmental trajectories of people conceived by assisted reproductive technology (ART). ART has led to over 10 million births and is an established and increasingly used treatment for infertility (disease affecting 1 in 6 couples). Addressing concerns that ART is a prenatal stressor that can have adverse effects on offspring long-term health is a major research priority however, existing evidence is limited by use of selected and small samples with short follow-up and lack of repeat measures.

Impact of research: 
The project will provide the highest possible quality evidence on the long-term physical and psychological developmental trajectories and key trajectory features in people born after ART. The findings can establish if offspring born by ART should be followed more closely by medical personnel with respect to their long-term physical and psychological development. The project will provide evidence-based guidelines and recommendations for healthcare providers, reproductive specialists, and legislators to ensure their optimal well-being and long-term health.
Date proposal received: 
Tuesday, 21 November, 2023
Date proposal approved: 
Monday, 27 November, 2023
Epidemiology, Fertility/infertility, Statistical methods, BMI, Cohort studies - attrition, bias, participant engagement, ethics, Development, Growth, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Offspring, Physical - activity, fitness, function