B4430 - CHARGE Metabolomics and Blood Pressure Replication - 23/10/2023

B number: 
Principal applicant name: 
Neil Goulding | Centre for Academic Child Health, Population Health Sciences, Bristol Medical School, University of Bristol (United Kingdom)
Professor Deborah Lawlor, Professor Bing Yu, Dr Taryn Alkis
Title of project: 
CHARGE Metabolomics and Blood Pressure Replication
Proposal summary: 

High blood pressure (BP) is a major risk factor for cardiovascular as well as non-cardiovascular diseases. Underlying molecular pathways related to BP regulation are not fully understood. The aim of the project is to identify ethnic-specific metabolites associated with cross-sectional measures of blood pressure levels and hypertension status. The project leaders have already found associations between specific metabolites and blood pressure levels or hypertension status in their discovery cohorts. Replication analyses will be conducted in several cohorts that are members of the CHARGE Metabolomics consortium, including ALSPAC.

Impact of research: 
A contribution to the identification of validated metabolomic biomarkers of blood pressure levels and hypertension
Date proposal received: 
Thursday, 19 October, 2023
Date proposal approved: 
Monday, 23 October, 2023
Epidemiology, Hypertension, NMR, Blood pressure