B4420 - Examining the relationship between autism spectrum disorder and paediatric incontinence using a polygenic risk score and Mendeli - 26/09/2023
B number:
B4420
Principal applicant name:
Carol Joinson | PHS (United Kingdom)
Co-applicants:
Dr Christina Dardani, Dr Kimberley Burrows, Mr Olly Bastiani
Title of project:
Examining the relationship between autism spectrum disorder and paediatric incontinence using a polygenic risk score and Mendeli
Proposal summary:
Autism spectrum disorder (ASD) is characterised by deficits in social interaction, communication, and language, as well as stereotyped and repetitive behaviours. There is strong evidence from observational studies for comorbidity between ASD and functional incontinence in children including enuresis (bedwetting), daytime urinary incontinence (DUI), and faecal incontinence (FI).
Impact of research:
The findings have the potential to advance understanding of the link between autism and childhood incontinence and could inform clinicians about which children are at increased risk of problems attaining continence, and therefore target them for early interventions
Date proposal received:
Monday, 25 September, 2023
Date proposal approved:
Tuesday, 26 September, 2023
Keywords:
Epidemiology, Incontinence, Statistical methods, Genetics