B4412 - Reproductive factors and the risk of pregnancy complications a student project linked to B4306 - 18/09/2023

B number: 
Principal applicant name: 
Fangkun Liu | Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China (China)
Ziwei Teng M.D.
Title of project: 
Reproductive factors and the risk of pregnancy complications: a student project linked to B4306
Proposal summary: 

This is a student project linked to my current project B4306. The reproductive factors including lifestyle, disease status, infection, medication use, nutrient supplements, physical activity, and mental health are associated with pregnancy complications. The adverse outcomes of pregnancy confront the world as a major challenge, with extensive impact on individuals, families, and societies at large. This study will take advantage of the data provided by the Avon Longitudinal Study of Parents and Children to quantify the risk of possible adverse outcomes of pregnancy, and present opportunities to reduce the burden associated with congenital disorders at a population level.

Impact of research: 
Our research may offer more insights into the etiologies of offspring developmental failure on the central nervous system, cognition and intelligence. This may help individuals to choose a more scientific way to avoid maternal exposure to bad factors and get close to good factors, to guarantee a healthy child, or help the governments and medical institutions to establish more appropriate strategies for better maternal and child health care.
Date proposal received: 
Tuesday, 5 September, 2023
Date proposal approved: 
Monday, 18 September, 2023
Mental health - Psychology, Psychiatry, Cognition, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Speech/language problem, Developmental disorders - autism, Cognitive impairment, Congenital abnormalities, Diabetes, Epilepsy, Infection, Learning difficulty, Mental health, GWAS, Medical imaging, Statistical methods, Birth outcomes, Blood pressure, Environment - enviromental exposure, pollution, Genome wide association study, Intelligence - memory, Mendelian randomisation, Mothers - maternal age, menopause, obstetrics, Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Nutrition - breast feeding, diet, Offspring, Psychology - personality, BMI, Physical - activity, fitness, function, Speech and language, Statistical methods, Cardiovascular, Childhood - childcare, childhood adversity, Cognition - cognitive function, Communication (including non-verbal), Development, Equipment - MRI, Endocrine - endocrine disrupters