B4377 - Lifecourse MR Consortium - 11/08/2023
B number:
B4377
Principal applicant name:
Genevieve Leyden | Univeristy of Bristol (United Kingdom)
Co-applicants:
Grace Power , Dr Eleanor Sanderson, Dr David Carslake, Dr Gibran Hemani, Professor George Davey Smith
Title of project:
Lifecourse MR Consortium
Proposal summary:
The aim of the Lifecourse-MR consortium is to collate data capturing life-stage specific exposures and investigate their effect on disease risk. As a contributing study in the consortium, GWAS summary statistics will be generated on the ALSPAC cohort for a variety of variables measured in early life and in adulthood. The data generated in this study will be used to help establish putative causal effects of life-stage specific exposures on health and disease.
Impact of research:
The output of this research will faciliate statistical methods to evaluate genetic effects which vary with age, and help evaluate lifecourse specific effects on disease outcome.
Date proposal received:
Monday, 7 August, 2023
Date proposal approved:
Friday, 11 August, 2023
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Cancer, Diabetes, Hypertension, Obesity, Cardiovascular disease, GWAS, Statistical methods, Ageing, BMI, Cardiovascular, Genetic epidemiology, Mendelian randomisation, Statistical methods