B4383 - Variance in adult height explained by blood-based DNA methylation - 01/08/2023
B number:
B4383
Principal applicant name:
Paul Yousefi | MRC Integrative Epidemiology Unit, University of Bristol
Co-applicants:
Matthew Suderman, Robert Hillary, Alesha Ann Hatton
Title of project:
Variance in adult height explained by blood-based DNA methylation
Proposal summary:
Height is a complex trait that is underscored by a combination of genetic and environmental factors. A large number of studies have defined the genetic basis of human height. Recent statistical genetics efforts have shown that ~40% of the variance in height can be explained by the combined additive effects of >10,000 individual variants. In this study, we will examine the utility of blood DNA methylation (DNAm) in capturing additional trait variance and in understanding the molecular architecture of height.
Impact of research:
The primary academic beneficiaries of this project will be epidemiologists and biological scientists who will gain insight into the role of the epigenome and it's relationship the phenotypic architecture of height.
Academics at all career stages, from PhD students to senior academics will have the opportunity to engage with and benefit from the research proposed.
Date proposal received:
Wednesday, 26 July, 2023
Date proposal approved:
Tuesday, 1 August, 2023
Keywords:
Molecular genetics and genomics, Microarrays, Epigenetics