B4382 - Blood-based epigenome-wide analyses of chronic low-grade inflammation - 01/08/2023
B number:
B4382
Principal applicant name:
Paul Yousefi | MRC Integrative Epidemiology Unit, University of Bristol
Co-applicants:
Matthew Suderman, Robert Hillary
Title of project:
Blood-based epigenome-wide analyses of chronic low-grade inflammation
Proposal summary:
Chronic inflammation is a hallmark of ageing and age-related disease states. The effectiveness of inflammatory proteins such as C-reactive protein (CRP) in assessing long-term inflammation is hindered by it's high within person variability. DNA methylation (DNAm) signatures of CRP may act as more reliable markers of chronic inflammation. This project will develop a series of DNAm predictors of CRP in the Generation Scotland Cohort and evaluate their performance in ALSPAC parents and children as well as several other UK based study populations.
Impact of research:
The primary academic beneficiaries of this project will be epidemiologists and biological scientists who will gain insight into the role of the epigenome and it's relationship with chronic inflammation. Researchers in the field of chronic disease epidemiology will benefit from determining whether DNA methylation can provide a more stable surrogate of inflammation than a single CRP measure.
Academics at all career stages, from PhD students to senior academics will have the opportunity to engage with and benefit from the research proposed.
Date proposal received:
Wednesday, 26 July, 2023
Date proposal approved:
Monday, 31 July, 2023
Keywords:
Epidemiology, Inflammation , Microarrays, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc.