B4341 - Lifelong understanding of cerebrovascular health - 26/07/2023

B number: 
Principal applicant name: 
Carole H. Sudre | University College London
Title of project: 
Lifelong understanding of cerebrovascular health
Proposal summary: 

Currently, vascular ill-health appears to be the most preventable component of cognitive decline in older age. There is however very limited understanding about the time at which signs of damage are already present in diseases that take decades to result in symptoms. In this project we will work to identify through imaging the markers that can help us quantify the health status of vessels and associated tissues in the brain. We will also work to better understand their relationship to known risk factors for cardiovascular disease.

Impact of research: 
This research will give a new perspective on cerebrovascular health in young adulthood and could be used to design personalised check-up for those deemed at risk with suggestions for early intervention and / or lifestyle changes.
Date proposal received: 
Tuesday, 27 June, 2023
Date proposal approved: 
Wednesday, 28 June, 2023
Neurology, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Cognitive impairment, Obesity, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Computer simulations/modelling/algorithms, Medical imaging, Proteomics, Statistical methods, Ageing, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Neurology, Blood pressure, BMI, Cardiovascular, Childhood - childcare, childhood adversity, Cognition - cognitive function, Development, Equipment - MRI, Kidney function