The association between maternal cardiometabolic markers and offspring cardiometabolic health has remained elusive. Barker et al. have postulated that the intrauterine environment and early-life development serve as potentially important determinants of cardiovascular disease (CVD) later in life. However, previous studies were constrained by limitations such as small sample sizes, short durations of follow-up, or inadequate control for confounding variables. Consequently, a systematic investigation of maternal gestational cardiometabolic biomarkers and their relationship with offspring cardiometabolic health in a large-scale cohort is warranted.