Dyslexia is a common and highly heritable conditions. New sequencing technologies allow us to identify potential mutations that might increase the risk of developing dyslexia. This project aims to identify such mutations and access whether they might contribute to dyslexia specifically or other related cognitive traits, e.g. language or mathematical abilities. We will conduct our analysis in clinical cohorts enriched for dyslexia cases and will follow the top results in the ALSPAC cohort to validate and better interpret our results.