B4362 - Metabolomic associations with liver enzymes and fatty liver disease - 28/06/2023

B number: 
Principal applicant name: 
Neil Goulding | Centre for Academic Child Health, Population Health Sciences, Bristol Medical School, University of Bristol (United Kingdom)
Professor Deborah Lawlor
Title of project: 
Metabolomic associations with liver enzymes and fatty liver disease
Proposal summary: 

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains poorly understood. Investigation of circulating metabolites may help in elucidating underlying mechanisms and identify new biomarkers for NAFLD. In this meta-analysis we will examine the association between plasma metabolites and NAFLD as well as liver enzymes using data from four CHARGE cohorts (Rotterdam Study – RS, Avon Longitudinal Study of Parents and Children – ALSPAC, Study of Latinos – SOL, Insulin Resistance Atherosclerosis Family Study – IRASFS).

Impact of research: 
A contribution to the identification of validated metabolomic biomarkers of liver enzymes and fatty liver disease
Date proposal received: 
Friday, 16 June, 2023
Date proposal approved: 
Wednesday, 28 June, 2023
Epidemiology, Fatty liver disease, NMR, Metabolic - metabolism