B4328 - Depression and hypertension comorbidity sleep as a potential mediator - 24/05/2023

B number: 
Principal applicant name: 
Yuning Zhang | University of Southampton (United Kingdom)
Ms Thea Dyson
Title of project: 
Depression and hypertension comorbidity: sleep as a potential mediator
Proposal summary: 

Depression and hypertension commonly co-occur. This comorbidity may be explained by HPA axis dysregulation which has associations with both hypertension and depression. Additionally, sleep problems are a known cause of HPA axis dysregulation, therefore, sleep may serve as a transdiagnositic marker, and potentailly intervention point, for both disorders. This research will focus on childhood and adolescence as previous research has only examined this relationships in adults, despite these conditions being prevalent in younger groups. Additionally, adulthood is a time when these conditions are already well-established. Through examining a younger sample, we can study the directionality and mediation of this relationship at a time when both conditions start to emerge.

Impact of research: 
This research will reveal the nature of the inter-relatedness between depression and hypertension during adolescence. Moreover, it will also provide insight into the role of sleeping quality for the common comorbidity between the two conditions. These findings will also have implications for interventions which could target sleep in preventing and reducing hypertension and depression comorbidity.
Date proposal received: 
Wednesday, 10 May, 2023
Date proposal approved: 
Wednesday, 24 May, 2023
Mental health - Psychology, Psychiatry, Cognition, Hypertension, Mental health, Statistical methods, Blood pressure, Sleep, Statistical methods