Whole exome sequencing (WES) is a method used to generate the sequence of all protein encoding regions of the human genome. ALSPAC has already obtained WES data from all available DNA from G1 participants (original children) and a subset of G0 parents. ALSPAC has been included in an MRC funded initiative to complete WES sequencing in some cohort studies. This will fund generating WES on approximately 11,000 samples from the remaining G0 parents and G2 (CoCo90s). This, together with existing data, will ensure WES is available from all suitable ALSPAC DNA samples.