B4266 - The LIQUID Study relationships between inflammatory markers and preclinical cardiometabolic phenotypes across the life course - 13/03/2023

B number: 
B4266
Principal applicant name: 
Toby Mansell | Murdoch Children's Research Institute (Australia)
Co-applicants: 
Prof. David Burgner, Prof. Deborah Lawlor, Prof. John Carlin, Prof. Markus Juonala
Title of project: 
The LIQUID Study: relationships between inflammatory markers and preclinical cardiometabolic phenotypes across the life course
Proposal summary: 

Inflammation is key to the development of cardiovascular and metabolic (cardiometabolic) diseases. However, it is largely unknown how inflammation markers relate to early measures of cardiometabolic risk, or how these relationships change as people get older. Using existing data collected by large international cohorts from infancy to old age, we will investigate the cross-sectional relationship between inflammation markers, metabolic health, and pre-clinical cardiovascular phenotypes at different stages of life. Data collected in mothers and offspring as part of ALSPAC will be an important addition to LIQUID. This project will help identify inflammation markers that are most informative for early cardiometabolic risk, which is critical for unlocking opportunities to intervene prior to the development of irreversible vascular damage.

Impact of research: 
The findings will provide new knowledge on the relationship between inflammatory markers across the life course and the extent to which inflammation contributes to cardiovascular risk. The data will inform the optimal timing and tools for primordial and primary prevention.
Date proposal received: 
Tuesday, 21 February, 2023
Date proposal approved: 
Monday, 6 March, 2023
Keywords: 
Epidemiology, Infection, Metabolomics, Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Blood pressure, BMI, Cardiovascular, Metabolic - metabolism