B4287 - Gene-by-environment genome-wide association study GWAS of lipid traits influenced by alcohol consumption in - 13/03/2023

B number: 
Principal applicant name: 
George Davey Smith | University of Bristol (United Kingdom)
Si Fang
Title of project: 
Gene-by-environment genome-wide association study (GWAS) of lipid traits influenced by alcohol consumption in
Proposal summary: 

The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium invites ALSPAC and Bristol researchers’ to take part in a large GWAS of lipid traits (incl. high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides). The main aims of CHARGE’s GWAS are to (1) identify novel loci for lipids trait separately by sex; (2) identify gene-alcohol consumption interaction effects on lipid traits separately by sex. These analyses will follow the ‘Phase II Analysis Plan for Alcohol and Lipids’ version 2.0 provided by CHARGE. Only GWAS summary statistics will be shared with CHARGE. Based on the GWAS results, subsequent analyses (e.g. validation of the gene-by-environment effects using longitudinal data of lipid traits, and Mendelian randomization) would be suggested by CHARGE.

Impact of research: 
This study will help identify novel genetic variants involved in lipid traits and how genetic variants affect these traits taking into account potential interaction with a lifestyle factor, i.e. alcohol consumption.
Date proposal received: 
Thursday, 9 March, 2023
Date proposal approved: 
Monday, 13 March, 2023
Genetic epidemiology (including association studies and mendelian randomisation), Lipids and alcohol consumption, GWAS, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc.