B4202 - Deciphering the genetic architecture of human facial morphological variations - 07/02/2023
B number:
B4202
Principal applicant name:
Jian Yang | School of Life Sciences, Westlake University (China)
Co-applicants:
Patrick Yi Feng Wen, PhD, Fei-Fei Cheng, MS
Title of project:
Deciphering the genetic architecture of human facial morphological variations
Proposal summary:
Human facial morphology is highly individualized. It is a complex trait jointly influenced by multiple genetic and environmental factors. In this project, state-of-the-art statistical genetics methods, including those developed by our teams, will be applied to dissect the genetic factors underpinning variations in human facial morphology. Our findings will advance knowledge on genetics of the craniofacial structure and will contribute to personalized and precision treatment of craniofacial diseases to improve quality of health care.
Impact of research:
This research will provide theoretical support for prevention and treatment of craniofacial malformations. Our findings are of value to craniomaxillofacial surgeons and orthodontists in planning personalized treatment plans, which will help improve the quality of health care provided to the patients.
Date proposal received:
Saturday, 19 November, 2022
Date proposal approved:
Tuesday, 22 November, 2022
Keywords:
Dentistry, Only data from healthy participants will be included. Findings of the study will shed light on prevention and treatment of craniofacial dysmorpholoy., GWAS, Face - face shape