B4232 - Investigating life-course effects of adiposity on inflammation - 11/01/2023

B number: 
Principal applicant name: 
Lucy Goudswaard | Population Health Sciences, University of Bristol (United Kingdom)
Professor Nicholas Timpson, Dr Laura Corbin, Dr David Hughes
Title of project: 
Investigating life-course effects of adiposity on inflammation
Proposal summary: 

Obesity (body mass index (BMI) of >30 kg/m2) is associated with low-grade chronic inflammation. Studies which have used a technique called Mendelian randomization (MR) have demonstrated that the relationship between body mass index and inflammatory proteins is causal. However, the timing of the onset of this inflammation is unclear. Inflammation could be a phenomenon which starts later in life as a result of a sustained high BMI over the life-course. Alternatively, it could be that a high BMI causes inflammation even in young children. Understanding the timing of this relationship is an important public health question as it could help in understanding the health impact of overweight/obesity in early life.

Impact of research: 
This work will help with understanding the effect of overweight/obesity in early life.
Date proposal received: 
Tuesday, 10 January, 2023
Date proposal approved: 
Wednesday, 11 January, 2023
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, Proteomics, Mendelian randomisation