B4212 - Improving treatment of menopausal symptoms by using genomics to understand aetiology - 22/12/2022
B number:
B4212
Principal applicant name:
Anna Murray | University of Exeter (UK)
Co-applicants:
Dr Kate Ruth, Dr Julia Prague, Professor Abigail Fraser, Professor Martha Hickey
Title of project:
Improving treatment of menopausal symptoms by using genomics to understand aetiology
Proposal summary:
Menopausal symptoms affect around 70% of women as they go through the menopause, but we don't know very much about what causes the various symptoms. It is not clear how different symptoms might be linked and who is at risk of developing them. We will use genomics to find the causes of a range of menopausal symptoms, including; hot flushes, sleep disturbance, mood changes and sexual dysfunction. We will develop a questionnaire to distribute to study participants to collect information about their symptoms and combine this with genomic data previously collected.
Impact of research:
We anticipate that our genomic studies will identify novel potential drug targets to treat the often debilitating symptoms of the menopause transition.
Date proposal received:
Wednesday, 7 December, 2022
Date proposal approved:
Wednesday, 14 December, 2022
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Menopause, Gene mapping, GWAS, Statistical methods, Endocrine - endocrine disrupters, Genetic epidemiology, Genetics, Genomics, Genome wide association study, Mothers - maternal age, menopause, obstetrics, Whole genome sequencing