This study will assess how early interventions change the natural course of atopic dermatitis. Data will be collected and analyzed from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort of 14,000 children from Avon, UK. The project will assess how early use of therapy, including topical and oral agents, changes the disease course of atopic dermatitis from birth to 18 years of age. Several studies in other inflammatory diseases such as Crohn’s and rheumatoid arthritis have established the value of aggressive intervention shortly after symptom onset in producing long-term disease modification. There may be opportunities to observe a similar effect with respect to atopic dermatitis, as well as related diseases of the atopic march. Second, this study will assess the development of major comorbidities including asthma, rhinitis, and food allergy, including severity and time course in the first 18 years of life.