B4209 - PhD project on Placentas adverse pregnancy outcomes and cardiometabolic health - 20/12/2022

B number: 
Principal applicant name: 
Abigail Fraser | Population Health Sciences, Bristol Medical School
Genevieve Monaghan, Dr Carolina Borges, Dr Rachael Freathy
Title of project: 
PhD project on Placentas, adverse pregnancy outcomes, and cardiometabolic health
Proposal summary: 

The placenta is a crucial organ of mammalian pregnancy, connecting mother and fetus. Impaired placentation and placental development and function are associated with common pregnancy complications including preeclmapsia, fetal growth restriction and preterm delivery.
Here we will investigate associations between placental weight, dimensions and number of cotyledons and pregnancy outcomes as well as the long term health of both mothers and their offspring. We will also use the genetic data in order to identify determinants of the placental traits.

Impact of research: 
A better understanding of the role of the placenta and its determinants in pregnancy and lifelong health
Date proposal received: 
Wednesday, 30 November, 2022
Date proposal approved: 
Thursday, 8 December, 2022
Epidemiology, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Statistical methods, Birth outcomes, Cardiovascular, Mothers - maternal age, menopause, obstetrics, Nutrition - breast feeding, diet, Offspring