B4225 - Polygenic risk score of asthma COPD and lung function and association with lung function outcomes - 19/12/2022

B number: 
Principal applicant name: 
Raquel Granell | MRC Integrative Epidemiology Unit
Prof Erik Melén, Dr Natalia Hernandez-Pacheco , Dr Christina Dardani
Title of project: 
Polygenic risk score of asthma, COPD and lung function, and association with lung function outcomes
Proposal summary: 

Genetic variants associated with lung function and susceptibility to airway diseases such as asthma or COPD might be implicated in lung function development from birth to adulthood. Here, we would be able to assess whether very low and low lung function trajectories are primarily associated with asthma, COPD, or lung function genetics, and related mechanisms. Disentangling the genetic factors derived from asthma, COPD, and lung function studies underlying the trajectory of poor pulmonary capacity across the lifespan could contribute to identifying new lung function biomarkers and to early prevent the development of chronic airway diseases. By using a PRS approach, we anticipate having better power to evaluate asthma and COPD mechanisms in lung function trajectories compared to a standard GWAS approach.

Impact of research: 
Date proposal received: 
Wednesday, 14 December, 2022
Date proposal approved: 
Monday, 19 December, 2022
Genetic epidemiology (including association studies and mendelian randomisation)