B4222 - Early-life vitamin D status and lung function in childhood and adolescence observational and mendelian randomization analyses - 19/12/2022

B number: 
B4222
Principal applicant name: 
Raquel Granell | MRC Integrative Epidemiology Unit (IEU)
Co-applicants: 
Dr Maribel Casas Sanahuja, Júlia Sangüesa Boix
Title of project: 
Early-life vitamin D status and lung function in childhood and adolescence: observational and mendelian randomization analyses.
Proposal summary: 

In this study we aim to analyse whether or not vitamin D levels during pregnancy influence lung development and, consequently, the occurrence of asthma and lung function performance in childhood and adolescence. To analyse these associations, we will use two methodologies. First, we will look at whether or not vitamin D levels measured in blood during pregnancy are associated with the onset of asthma and lung function parameters at 8-9 years and 15-16 years in the ALSPAC cohort. Since this association may be influenced by many confounding factors such as lifestyle, socio-economic status, the season of the year when the blood was obtained, we will use Mendelian Randomisation to overcome this limitation. We will analyse whether or not genetic variants that predispose to having low levels of vitamin D are associated with a greater predisposition to having asthma and poorer lung function in childhood and adolescence. We will use data from 4 different European cohorts and one Australian cohort and, after doing all the analysis separately, we will collect the results and do a meta-analysis using all data.

Impact of research: 
High impact publication
Date proposal received: 
Tuesday, 13 December, 2022
Date proposal approved: 
Monday, 19 December, 2022
Keywords: 
Genetics, Respiratory - asthma