B4205 - The intergenerational links between PRS of ADHD in mothers and childhood maltreatment in their children - 06/12/2022

B number: 
B4205
Principal applicant name: 
Helen Minnis | supervisor (UK)
Co-applicants: 
Evi Bali
Title of project: 
The intergenerational links between PRS of ADHD in mothers and childhood maltreatment in their children
Proposal summary: 

Childhood maltreatment has a profound impact on both the short- and long-term wellbeing of children. Specifically, children with autism and those with attention deficit/hyperactivity disorder have a higher risk to experience maltreatment than those with typical development. However, the reasons why this is happening, are unclear. Two studies will be conducted. The first study will investigate the relationship between childhood maltreatment and ADHD. Studies support an association between ADHD and maltreatment: Children with ADHD have higher risk of experience maltreatment than those without ADHD, as well as people who suffered childhood maltreatment have high levels of ADHD symptoms and diagnosis. Also, parental ADHD and/or experience of maltreatment could influence the strength of this association. So, we will define and analyse how genetic and social factors affect the association between ADHD and childhood maltreatment, and then how this could be developed through generations. Having assessed and display the association between ADHD and childhood maltreatment, the second study will go a step forward searching the experience of physical abuse and harsh parenting in children with ADHD and children with autism. We will conduct a comparison between children with ADHD and children with autism trying to understand how the different traits of each condition may affect different the risk of physical abuse and harsh parenting.

Impact of research: 
The immediate impact of this research will likely be at least 2 peer reviewed publication in a general journal (i.e. PLOS Medicine). We aim to present and discuss results in a way that is robust enough for academics but is accessible and relevant to clinicians and public health practitioners, ultimately encouraging greater attention for the association between ADHD and childhood adverse experience, like maltreatment.
Date proposal received: 
Monday, 21 November, 2022
Date proposal approved: 
Tuesday, 22 November, 2022
Keywords: 
Epidemiology, Developmental disorders - autism, Mental health, GWAS, Statistical methods, Childhood - childcare, childhood adversity, Genetic epidemiology, Parenting