B4198 - Revisiting the associations between asthma and psychotic experiences - 21/11/2022

B number: 
Principal applicant name: 
Golam Khandaker | Head, Immunopsychiatry Programme, MRC IEU, Bristol Medical School (United Kingdom)
Dr Christina Dardani
Title of project: 
Revisiting the associations between asthma and psychotic experiences
Proposal summary: 

Asthma is a chronic condition influencing breathing and characterised by breathlessness, coughing and chest tightness. Asthma can be triggered by exposure to several allergens (e.g., pollen) or infections and is considered predominantly an inflammatory condition. There is increasing evidence suggesting that asthma in childhood may be linked to a number of adverse mental health outcomes including psychotic disorders such as schizophrenia and bipolar disorder. Specifically, previous studies using the ALSPAC resource have found evidence of associations between asthma at age 10 and psychotic experiences at age 13. Furthermore, studies using large nationwide data from Sweden, found that asthma in parents was associated with bipolar disorder in their children. The reasons underlying these associations are largely unknown and several explanations have been hypothesised. For example, it has been proposed that inflammatory mechanisms involved in asthma might be causal for psychotic disorders. Gaining a better understanding on the relationship between asthma and psychotic disorders can have important implications towards uncovering drug targets for these chronic mental health conditions.

Impact of research: 
Date proposal received: 
Monday, 14 November, 2022
Date proposal approved: 
Monday, 21 November, 2022
Epidemiology, Respiratory - asthma, Statistical methods, Mendelian randomisation