B4188 - Parental Type 2 Diabetes and Cardiovascular disease polygenic risk scores by offspring birthweight and placental weight - 14/11/2022

B number: 
B4188
Principal applicant name: 
Charlie Hatcher | University of Bristol
Co-applicants: 
Professor Nicholas Timpson
Title of project: 
Parental Type 2 Diabetes and Cardiovascular disease polygenic risk scores by offspring birthweight and placental weight
Proposal summary: 

Birth weight (BW) and placental weight (PW) have been associated with adult health outcomes, and a genetic component for this relationship has been established. Similar associations between offspring BW and PW and parental health have been found in observational studies. We aim to investigate the association of parental diabetes and cardiovascular disease risk variants with offspring BW and PW.

Impact of research: 
Date proposal received: 
Tuesday, 1 November, 2022
Date proposal approved: 
Monday, 7 November, 2022
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Diabetes, Statistical methods, Genome wide association study