B4194 - Genetic Determinants of Longitudinal Changes in Anthropometric Traits - 09/11/2022

B number: 
Principal applicant name: 
Loic Yengo | Institute for Molecular Bioscience - The University of Queensland (Australia)
Dr Nicole Warrington, Mr Samuel McEwan, Dr Geng Wang , Dr Christopher Flatley , Professor Kate Tilling, Professor Deborah Lawlor
Title of project: 
Genetic Determinants of Longitudinal Changes in Anthropometric Traits
Proposal summary: 

This project aims to identify and characterize the contribution of genetic variation to growth-related traits. One part of this project will be conducted in collaboration with international consortia to identify genetic variants associated with height and body mass index (BMI) variation across childhood. The other part of the project will focus on genetic variants already associated with adult traits (height and BMI) and will characterise the critical time periods in childhood development when these variants start and stop to exert their effects.

Impact of research: 
Our research will expand knowledge of (i) the genetic determinants of healthy growth and their interplay with the environment and (ii) illuminate how maternal characteristics may impact children's future health.
Date proposal received: 
Tuesday, 8 November, 2022
Date proposal approved: 
Tuesday, 8 November, 2022
Genetic epidemiology (including association studies and mendelian randomisation), Diabetes, Hypertension, Obesity, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Gene mapping, GWAS, Statistical methods, Blood pressure, BMI, Mendelian randomisation, Mothers - maternal age, menopause, obstetrics, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Puberty, Statistical methods, Cardiovascular, Development, Genetic epidemiology, Genetics, Genomics, Genome wide association study, Growth, Hormones - cortisol, IGF, thyroid